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Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

Author

Listed:
  • Adrien Decorsière

    (University Medical Centre (C.M.U.))

  • Henrik Mueller

    (University Medical Centre (C.M.U.)
    †Present addresses: Roche Pharmaceutical Research & Early Development, Infectious Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland (H.M.); The Netherlands Cancer Institute, Division of Biological Stress Response, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands (P.C.v.B.).)

  • Pieter C. van Breugel

    (University Medical Centre (C.M.U.)
    †Present addresses: Roche Pharmaceutical Research & Early Development, Infectious Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland (H.M.); The Netherlands Cancer Institute, Division of Biological Stress Response, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands (P.C.v.B.).)

  • Fabien Abdul

    (University Medical Centre (C.M.U.))

  • Laetitia Gerossier

    (CRCL, INSERM U1052, CNRS 5286, Université de Lyon)

  • Rudolf K. Beran

    (Gilead Sciences, Inc.)

  • Christine M. Livingston

    (Gilead Sciences, Inc.)

  • Congrong Niu

    (Gilead Sciences, Inc.)

  • Simon P. Fletcher

    (Gilead Sciences, Inc.)

  • Olivier Hantz

    (CRCL, INSERM U1052, CNRS 5286, Université de Lyon)

  • Michel Strubin

    (University Medical Centre (C.M.U.))

Abstract

Hepatitis B virus X protein stimulates transcription from the viral DNA episome by hijacking the host ubiquitin machinery to target the Smc5/6 complex for degradation.

Suggested Citation

  • Adrien Decorsière & Henrik Mueller & Pieter C. van Breugel & Fabien Abdul & Laetitia Gerossier & Rudolf K. Beran & Christine M. Livingston & Congrong Niu & Simon P. Fletcher & Olivier Hantz & Michel S, 2016. "Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor," Nature, Nature, vol. 531(7594), pages 386-389, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7594:d:10.1038_nature17170
    DOI: 10.1038/nature17170
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