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Co-ordinated ocular development from human iPS cells and recovery of corneal function

Author

Listed:
  • Ryuhei Hayashi

    (Osaka University Graduate School of Medicine
    Osaka University Graduate School of Medicine)

  • Yuki Ishikawa

    (Osaka University Graduate School of Medicine)

  • Yuzuru Sasamoto

    (Osaka University Graduate School of Medicine)

  • Ryosuke Katori

    (Osaka University Graduate School of Medicine)

  • Naoki Nomura

    (Osaka University Graduate School of Medicine)

  • Tatsuya Ichikawa

    (Osaka University Graduate School of Medicine)

  • Saori Araki

    (Osaka University Graduate School of Medicine)

  • Takeshi Soma

    (Osaka University Graduate School of Medicine)

  • Satoshi Kawasaki

    (Osaka University Graduate School of Medicine)

  • Kiyotoshi Sekiguchi

    (Laboratory of Extracellular Matrix Biochemistry, Institute for Protein Research, Osaka University)

  • Andrew J. Quantock

    (Structural Biophysics Group, School of Optometry and Vision Sciences, College of Biomedical and Life Sciences, Cardiff University)

  • Motokazu Tsujikawa

    (Osaka University Graduate School of Medicine)

  • Kohji Nishida

    (Osaka University Graduate School of Medicine)

Abstract

A protocol has been developed to use human induced pluripotent stem cells to obtain a self-formed ectodermal autonomous multizone, which includes distinct cell lineages of the eye, including the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium that can be expanded to form a functional corneal epithelium when transplanted to an animal model of corneal visual impairment.

Suggested Citation

  • Ryuhei Hayashi & Yuki Ishikawa & Yuzuru Sasamoto & Ryosuke Katori & Naoki Nomura & Tatsuya Ichikawa & Saori Araki & Takeshi Soma & Satoshi Kawasaki & Kiyotoshi Sekiguchi & Andrew J. Quantock & Motokaz, 2016. "Co-ordinated ocular development from human iPS cells and recovery of corneal function," Nature, Nature, vol. 531(7594), pages 376-380, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7594:d:10.1038_nature17000
    DOI: 10.1038/nature17000
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