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NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

Author

Listed:
  • Chi Ma

    (Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Aparna H. Kesarwala

    (Radiation Oncology Branch, National Cancer Institute, National Institutes of Health)

  • Tobias Eggert

    (Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • José Medina-Echeverz

    (Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • David E. Kleiner

    (Laboratory of Pathology, National Cancer Institute, National Institutes of Health)

  • Ping Jin

    (Cell Processing Section, Clinical Center, National Institutes of Health)

  • David F. Stroncek

    (Cell Processing Section, Clinical Center, National Institutes of Health)

  • Masaki Terabe

    (Vaccine Branch, National Cancer Institute, National Institutes of Health)

  • Veena Kapoor

    (Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health)

  • Mei ElGindi

    (Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Miaojun Han

    (Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Angela M. Thornton

    (Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Haibo Zhang

    (Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health)

  • Michèle Egger

    (Institute of Surgical Pathology, University and University Hospital Zurich)

  • Ji Luo

    (Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health)

  • Dean W. Felsher

    (Stanford University)

  • Daniel W. McVicar

    (Cancer and Inflammation Program, National Cancer Institute)

  • Achim Weber

    (Institute of Surgical Pathology, University and University Hospital Zurich)

  • Mathias Heikenwalder

    (Institute of Virology, Technische Universität München/Helmholtz Zentrum München,
    German Cancer Research Center (DKFZ))

  • Tim F. Greten

    (Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is shown to promote hepatocellular carcinoma through the generation of linoleic acid, disruption of mitochondrial function and selective loss of CD4+ T cells, leading to impaired anti-tumour immunity.

Suggested Citation

  • Chi Ma & Aparna H. Kesarwala & Tobias Eggert & José Medina-Echeverz & David E. Kleiner & Ping Jin & David F. Stroncek & Masaki Terabe & Veena Kapoor & Mei ElGindi & Miaojun Han & Angela M. Thornton & , 2016. "NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis," Nature, Nature, vol. 531(7593), pages 253-257, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7593:d:10.1038_nature16969
    DOI: 10.1038/nature16969
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    Cited by:

    1. Qilun Zhang & Xuting Shen & Xin Yuan & Jing Huang & Yaling Zhu & Tengteng Zhu & Tao Zhang & Haibo Wu & Qian Wu & Yinguang Fan & Jing Ni & Leilei Meng & Anyuan He & Chaowei Shi & Hao Li & Qingsong Hu &, 2024. "Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Kieran English & Rain Kwan & Lauren E. Holz & Claire McGuffog & Jelte M. M. Krol & Daryan Kempe & Tsuneyasu Kaisho & William R. Heath & Leszek Lisowski & Maté Biro & Geoffrey W. McCaughan & David G. B, 2024. "A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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