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Crystal structure of eukaryotic translation initiation factor 2B

Author

Listed:
  • Kazuhiro Kashiwagi

    (Graduate School of Science, The University of Tokyo, Bunkyo-ku
    RIKEN Systems and Structural Biology Center
    RIKEN Center for Life Science Technologies)

  • Mari Takahashi

    (RIKEN Center for Life Science Technologies)

  • Madoka Nishimoto

    (RIKEN Center for Life Science Technologies)

  • Takuya B. Hiyama

    (Graduate School of Science, The University of Tokyo, Bunkyo-ku
    RIKEN Systems and Structural Biology Center)

  • Toshiaki Higo

    (RIKEN Systems and Structural Biology Center
    RIKEN Center for Life Science Technologies)

  • Takashi Umehara

    (RIKEN Systems and Structural Biology Center
    RIKEN Center for Life Science Technologies)

  • Kensaku Sakamoto

    (RIKEN Systems and Structural Biology Center
    RIKEN Center for Life Science Technologies)

  • Takuhiro Ito

    (Graduate School of Science, The University of Tokyo, Bunkyo-ku
    RIKEN Systems and Structural Biology Center
    RIKEN Center for Life Science Technologies)

  • Shigeyuki Yokoyama

    (Graduate School of Science, The University of Tokyo, Bunkyo-ku
    RIKEN Systems and Structural Biology Center
    RIKEN Structural Biology Laboratory)

Abstract

The crystal structure of Schizosaccharomyces pombe guanine nucleotide exchange factor eIF2B, providing a structural framework for the eIF2B-mediated mechanism of stress-induced translational control.

Suggested Citation

  • Kazuhiro Kashiwagi & Mari Takahashi & Madoka Nishimoto & Takuya B. Hiyama & Toshiaki Higo & Takashi Umehara & Kensaku Sakamoto & Takuhiro Ito & Shigeyuki Yokoyama, 2016. "Crystal structure of eukaryotic translation initiation factor 2B," Nature, Nature, vol. 531(7592), pages 122-125, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7592:d:10.1038_nature16991
    DOI: 10.1038/nature16991
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    Cited by:

    1. Kazuhiro Kashiwagi & Yuichi Shichino & Tatsuya Osaki & Ayako Sakamoto & Madoka Nishimoto & Mari Takahashi & Mari Mito & Friedemann Weber & Yoshiho Ikeuchi & Shintaro Iwasaki & Takuhiro Ito, 2021. "eIF2B-capturing viral protein NSs suppresses the integrated stress response," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Michael Schoof & Lan Wang & J. Zachery Cogan & Rosalie E. Lawrence & Morgane Boone & Jennifer Deborah Wuerth & Adam Frost & Peter Walter, 2021. "Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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