IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v531y2016i7592d10.1038_nature16951.html
   My bibliography  Save this article

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

Author

Listed:
  • Faranak Fattahi

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research
    Weill Graduate School of Medical Sciences of Cornell University)

  • Julius A Steinbeck

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Sonja Kriks

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Jason Tchieu

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Bastian Zimmer

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Sarah Kishinevsky

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research
    Weill Graduate School of Medical Sciences of Cornell University)

  • Nadja Zeltner

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Yvonne Mica

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research
    † Present address: Thermo Fisher Scientific, Waltham, Massachusetts 02451, USA.)

  • Wael El-Nachef

    (Molecular Pharmacology Program)

  • Huiyong Zhao

    (Molecular Pharmacology Program)

  • Elisa de Stanchina

    (Molecular Pharmacology Program)

  • Michael D. Gershon

    (Columbia University, College of Physicians and Surgeons)

  • Tracy C. Grikscheit

    (Children’s Hospital Los Angeles, Pediatric Surgery)

  • Shuibing Chen

    (Weill Medical College of Cornell University)

  • Lorenz Studer

    (The Center for Stem Cell Biology
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

Abstract

A differentiation protocol to obtain enteric nervous system (ENS) progenitors and a range of neurons from human pluripotent stem cells is developed; the cells can migrate and graft to the colon of a chick embryo and an adult mouse colon, including in a mouse model of Hirschsprung disease, in which a functional rescue is observed.

Suggested Citation

  • Faranak Fattahi & Julius A Steinbeck & Sonja Kriks & Jason Tchieu & Bastian Zimmer & Sarah Kishinevsky & Nadja Zeltner & Yvonne Mica & Wael El-Nachef & Huiyong Zhao & Elisa de Stanchina & Michael D. G, 2016. "Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease," Nature, Nature, vol. 531(7592), pages 105-109, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7592:d:10.1038_nature16951
    DOI: 10.1038/nature16951
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature16951
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature16951?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Juliane Tschuck & Vidya Padmanabhan Nair & Ana Galhoz & Carole Zaratiegui & Hin-Man Tai & Gabriele Ciceri & Ina Rothenaigner & Jason Tchieu & Brent R. Stockwell & Lorenz Studer & Daphne S. Cabianca & , 2024. "Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Dianne Lumaquin-Yin & Emily Montal & Eleanor Johns & Arianna Baggiolini & Ting-Hsiang Huang & Yilun Ma & Charlotte LaPlante & Shruthy Suresh & Lorenz Studer & Richard M. White, 2023. "Lipid droplets are a metabolic vulnerability in melanoma," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Weikang Pan & Ahmed A. Rahman & Takahiro Ohkura & Rhian Stavely & Kensuke Ohishi & Christopher Y. Han & Abigail Leavitt & Aki Kashiwagi & Alan J. Burns & Allan M. Goldstein & Ryo Hotta, 2024. "Autologous cell transplantation for treatment of colorectal aganglionosis in mice," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Hsueh-Fu Wu & Wenxin Yu & Kenyi Saito-Diaz & Chia-Wei Huang & Joseph Carey & Frances Lefcort & Gerald W. Hart & Hong-Xiang Liu & Nadja Zeltner, 2022. "Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:531:y:2016:i:7592:d:10.1038_nature16951. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.