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Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

Author

Listed:
  • Fabricio Loayza-Puch

    (The Netherlands Cancer Institute)

  • Koos Rooijers

    (The Netherlands Cancer Institute)

  • Levi C. M. Buil

    (The Netherlands Cancer Institute)

  • Jelle Zijlstra

    (The Netherlands Cancer Institute)

  • Joachim F. Oude Vrielink

    (The Netherlands Cancer Institute)

  • Rui Lopes

    (The Netherlands Cancer Institute)

  • Alejandro Pineiro Ugalde

    (The Netherlands Cancer Institute)

  • Pieter van Breugel

    (The Netherlands Cancer Institute)

  • Ingrid Hofland

    (Core Facility Molecular Pathology and Biobanking, The Netherlands Cancer Institute)

  • Jelle Wesseling

    (Molecular Pathology, The Netherlands Cancer Institute)

  • Olaf van Tellingen

    (The Netherlands Cancer Institute)

  • Axel Bex

    (Division of Surgical Oncology, Department of Urology The Netherlands Cancer Institute)

  • Reuven Agami

    (The Netherlands Cancer Institute
    Erasmus University Medical Center)

Abstract

Tumours can require certain amino acids for their proliferation, and the diricore method described here helps to identify such restrictive amino acids; using this method in kidney cancer tissue and breast carcinoma cells, the authors observe an association between proline deficiency and upregulation of PYCR1, an enzyme required for proline synthesis.

Suggested Citation

  • Fabricio Loayza-Puch & Koos Rooijers & Levi C. M. Buil & Jelle Zijlstra & Joachim F. Oude Vrielink & Rui Lopes & Alejandro Pineiro Ugalde & Pieter van Breugel & Ingrid Hofland & Jelle Wesseling & Olaf, 2016. "Tumour-specific proline vulnerability uncovered by differential ribosome codon reading," Nature, Nature, vol. 530(7591), pages 490-494, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7591:d:10.1038_nature16982
    DOI: 10.1038/nature16982
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    Cited by:

    1. Mirjana Malnar Črnigoj & Urša Čerček & Xiaoke Yin & Manh Tin Ho & Barbka Repic Lampret & Manuela Neumann & Andreas Hermann & Guy Rouleau & Beat Suter & Manuel Mayr & Boris Rogelj, 2023. "Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Joana Silva & Ferhat Alkan & Sofia Ramalho & Goda Snieckute & Stefan Prekovic & Ana Krotenberg Garcia & Santiago Hernández-Pérez & Rob Kammen & Danielle Barnum & Liesbeth Hoekman & Maarten Altelaar & , 2022. "Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Xiangli Jiang & Ali Hyder Baig & Giuliana Palazzo & Rossella Pizzo & Toman Bortecen & Sven Groessl & Esther A. Zaal & Cinthia Claudia Amaya Ramirez & Alexander Kowar & Daniela Aviles-Huerta & Celia R., 2024. "P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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