IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v530y2016i7591d10.1038_nature16982.html
   My bibliography  Save this article

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

Author

Listed:
  • Fabricio Loayza-Puch

    (The Netherlands Cancer Institute)

  • Koos Rooijers

    (The Netherlands Cancer Institute)

  • Levi C. M. Buil

    (The Netherlands Cancer Institute)

  • Jelle Zijlstra

    (The Netherlands Cancer Institute)

  • Joachim F. Oude Vrielink

    (The Netherlands Cancer Institute)

  • Rui Lopes

    (The Netherlands Cancer Institute)

  • Alejandro Pineiro Ugalde

    (The Netherlands Cancer Institute)

  • Pieter van Breugel

    (The Netherlands Cancer Institute)

  • Ingrid Hofland

    (Core Facility Molecular Pathology and Biobanking, The Netherlands Cancer Institute)

  • Jelle Wesseling

    (Molecular Pathology, The Netherlands Cancer Institute)

  • Olaf van Tellingen

    (The Netherlands Cancer Institute)

  • Axel Bex

    (Division of Surgical Oncology, Department of Urology The Netherlands Cancer Institute)

  • Reuven Agami

    (The Netherlands Cancer Institute
    Erasmus University Medical Center)

Abstract

Tumours can require certain amino acids for their proliferation, and the diricore method described here helps to identify such restrictive amino acids; using this method in kidney cancer tissue and breast carcinoma cells, the authors observe an association between proline deficiency and upregulation of PYCR1, an enzyme required for proline synthesis.

Suggested Citation

  • Fabricio Loayza-Puch & Koos Rooijers & Levi C. M. Buil & Jelle Zijlstra & Joachim F. Oude Vrielink & Rui Lopes & Alejandro Pineiro Ugalde & Pieter van Breugel & Ingrid Hofland & Jelle Wesseling & Olaf, 2016. "Tumour-specific proline vulnerability uncovered by differential ribosome codon reading," Nature, Nature, vol. 530(7591), pages 490-494, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7591:d:10.1038_nature16982
    DOI: 10.1038/nature16982
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature16982
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature16982?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mirjana Malnar Črnigoj & Urša Čerček & Xiaoke Yin & Manh Tin Ho & Barbka Repic Lampret & Manuela Neumann & Andreas Hermann & Guy Rouleau & Beat Suter & Manuel Mayr & Boris Rogelj, 2023. "Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Joana Silva & Ferhat Alkan & Sofia Ramalho & Goda Snieckute & Stefan Prekovic & Ana Krotenberg Garcia & Santiago Hernández-Pérez & Rob Kammen & Danielle Barnum & Liesbeth Hoekman & Maarten Altelaar & , 2022. "Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:530:y:2016:i:7591:d:10.1038_nature16982. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.