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Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

Author

Listed:
  • Yuan Mei

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Patricia Monteiro

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology
    PhD Programme in Experimental Biology and Biomedicine (PDBEB), Center for Neuroscience and Cell Biology, University of Coimbra
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard)

  • Yang Zhou

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Jin-Ah Kim

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Xian Gao

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology
    Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitve Science, East China Normal University)

  • Zhanyan Fu

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard)

  • Guoping Feng

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard)

Abstract

Re-expression of the Shank3 gene in adult mice results in improvements in synaptic protein composition and spine density in the striatum; Shank3 also rescues autism-like features such as social interaction and grooming behaviour, and the results suggest that aspects of autism spectrum disorders may be reversible in adulthood.

Suggested Citation

  • Yuan Mei & Patricia Monteiro & Yang Zhou & Jin-Ah Kim & Xian Gao & Zhanyan Fu & Guoping Feng, 2016. "Adult restoration of Shank3 expression rescues selective autistic-like phenotypes," Nature, Nature, vol. 530(7591), pages 481-484, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7591:d:10.1038_nature16971
    DOI: 10.1038/nature16971
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    Cited by:

    1. Diana Rodrigues & Luis Jacinto & Margarida Falcão & Ana Carolina Castro & Alexandra Cruz & Cátia Santa & Bruno Manadas & Fernanda Marques & Nuno Sousa & Patricia Monteiro, 2022. "Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Myung Chung & Katsutoshi Imanaka & Ziyan Huang & Akiyuki Watarai & Mu-Yun Wang & Kentaro Tao & Hirotaka Ejima & Tomomi Aida & Guoping Feng & Teruhiro Okuyama, 2024. "Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Elise C. Cope & Samantha H. Wang & Renée C. Waters & Isha R. Gore & Betsy Vasquez & Blake J. Laham & Elizabeth Gould, 2023. "Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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