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Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

Author

Listed:
  • Christian Schläger

    (Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen)

  • Henrike Körner

    (Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen)

  • Martin Krueger

    (Institute of Anatomy, University of Leipzig)

  • Stefano Vidoli

    (University of Rome La Sapienza)

  • Michael Haberl

    (Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen)

  • Dorothee Mielke

    (University Medical Centre Göttingen)

  • Elke Brylla

    (Institute of Anatomy, University of Leipzig)

  • Thomas Issekutz

    (Division of Immunology, Department of Pediatrics Dalhousie University)

  • Carlos Cabañas

    (Centro de Biología Molecular Severo Ochoa)

  • Peter J. Nelson

    (Medical Clinic and Policlinic IV, Ludwig-Maximilians-University of Munich)

  • Tjalf Ziemssen

    (University Hospital)

  • Veit Rohde

    (University Medical Centre Göttingen)

  • Ingo Bechmann

    (Institute of Anatomy, University of Leipzig)

  • Dmitri Lodygin

    (Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen)

  • Francesca Odoardi

    (Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen)

  • Alexander Flügel

    (Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen
    Max-Planck-Institute for Experimental Medicine)

Abstract

By investigating trafficking of autoreactive T cells into the CSF during experimental autoimmune encephalitis, the authors find that T cells enter the CSF from the leptomeninges, and that commuting between the leptomeninges and the CSF is regulated by integrin adhesive forces triggered by T-cell activation and/or chemokines.

Suggested Citation

  • Christian Schläger & Henrike Körner & Martin Krueger & Stefano Vidoli & Michael Haberl & Dorothee Mielke & Elke Brylla & Thomas Issekutz & Carlos Cabañas & Peter J. Nelson & Tjalf Ziemssen & Veit Rohd, 2016. "Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid," Nature, Nature, vol. 530(7590), pages 349-353, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7590:d:10.1038_nature16939
    DOI: 10.1038/nature16939
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