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Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

Author

Listed:
  • James Y. Chen

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine)

  • Masanori Miyanishi

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine)

  • Sean K. Wang

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine)

  • Satoshi Yamazaki

    (Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo)

  • Rahul Sinha

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine)

  • Kevin S. Kao

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine)

  • Jun Seita

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Debashis Sahoo

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    †Present address: Department of Pediatrics and Department of Computer Science and Engineering, University of California San Diego, San Diego, California 92123, USA.)

  • Hiromitsu Nakauchi

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo)

  • Irving L. Weissman

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine)

Abstract

Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology in situ; here the authors have found that expression of a single gene, Hoxb5, defines haematopoietic stem cells with long-term reconstitution capacity, and that these cells are mainly found in direct contact with endothelial cells.

Suggested Citation

  • James Y. Chen & Masanori Miyanishi & Sean K. Wang & Satoshi Yamazaki & Rahul Sinha & Kevin S. Kao & Jun Seita & Debashis Sahoo & Hiromitsu Nakauchi & Irving L. Weissman, 2016. "Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche," Nature, Nature, vol. 530(7589), pages 223-227, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7589:d:10.1038_nature16943
    DOI: 10.1038/nature16943
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