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Structure- and function-based design of Plasmodium-selective proteasome inhibitors

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  • Hao Li

    (Stanford University School of Medicine
    Stanford University School of Medicine
    †Present addresses: Molecular Engineering Laboratory, Biomedical Sciences Institute, Agency for Science, Technology and Research, Singapore 138673 (H.L.); Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA (A.J.O.).)

  • Anthony J. O’Donoghue

    (University of California San Francisco
    †Present addresses: Molecular Engineering Laboratory, Biomedical Sciences Institute, Agency for Science, Technology and Research, Singapore 138673 (H.L.); Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA (A.J.O.).)

  • Wouter A. van der Linden

    (Stanford University School of Medicine)

  • Stanley C. Xie

    (Bio21 Institute, University of Melbourne)

  • Euna Yoo

    (Stanford University School of Medicine)

  • Ian T. Foe

    (Stanford University School of Medicine)

  • Leann Tilley

    (Bio21 Institute, University of Melbourne)

  • Charles S. Craik

    (University of California San Francisco)

  • Paula C. A. da Fonseca

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus)

  • Matthew Bogyo

    (Stanford University School of Medicine)

Abstract

Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human proteasome to allow selective targeting with inhibitors.

Suggested Citation

  • Hao Li & Anthony J. O’Donoghue & Wouter A. van der Linden & Stanley C. Xie & Euna Yoo & Ian T. Foe & Leann Tilley & Charles S. Craik & Paula C. A. da Fonseca & Matthew Bogyo, 2016. "Structure- and function-based design of Plasmodium-selective proteasome inhibitors," Nature, Nature, vol. 530(7589), pages 233-236, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7589:d:10.1038_nature16936
    DOI: 10.1038/nature16936
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    Cited by:

    1. Jan Silhan & Pavla Fajtova & Jitka Bartosova & Brianna M. Hurysz & Jehad Almaliti & Yukiko Miyamoto & Lars Eckmann & William H. Gerwick & Anthony J. O’Donoghue & Evzen Boura, 2024. "Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Hao-Chi Hsu & Daqiang Li & Wenhu Zhan & Jianxiang Ye & Yi Jing Liu & Annie Leung & Junling Qin & Benigno Crespo & Francisco-Javier Gamo & Hao Zhang & Liwang Cui & Alison Roth & Laura A. Kirkman & Huil, 2023. "Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Ruixue Xu & Lirong Lin & Zhiwei Jiao & Rui Liang & Yazhen Guo & Yixin Zhang & Xiaoxu Shang & Yuezhou Wang & Xu Wang & Luming Yao & Shengfa Liu & Xianming Deng & Jing Yuan & Xin-zhuan Su & Jian Li, 2024. "Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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