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Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells

Author

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  • Maud de Dieuleveult

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Kuangyu Yen

    (Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, School of Basic Medical Sciences, Southern Medical University
    Center for Eukaryotic Gene Regulation, The Pennsylvania State University)

  • Isabelle Hmitou

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Arnaud Depaux

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Fayçal Boussouar

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay
    Present address:INSERM, U823; Université Grenoble Alpes; Institut Albert Bonniot Grenoble, 38700 Grenoble, France)

  • Daria Bou Dargham

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Sylvie Jounier

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Hélène Humbertclaude

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Florence Ribierre

    (Centre National de Génotypage, Institut de Génomique)

  • Céline Baulard

    (Centre National de Génotypage, Institut de Génomique)

  • Nina P. Farrell

    (Center for Eukaryotic Gene Regulation, The Pennsylvania State University)

  • Bongsoo Park

    (Center for Eukaryotic Gene Regulation, The Pennsylvania State University)

  • Céline Keime

    (IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), INSERM, U964, CNRS, UMR7104, Université de Strasbourg)

  • Lucie Carrière

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Soizick Berlivet

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Marta Gut

    (Centre Nacional D’Anàlisi Genòmica)

  • Ivo Gut

    (Centre Nacional D’Anàlisi Genòmica)

  • Michel Werner

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Jean-François Deleuze

    (Centre National de Génotypage, Institut de Génomique)

  • Robert Olaso

    (Centre National de Génotypage, Institut de Génomique)

  • Jean-Christophe Aude

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

  • Sophie Chantalat

    (Centre National de Génotypage, Institut de Génomique)

  • B. Franklin Pugh

    (Center for Eukaryotic Gene Regulation, The Pennsylvania State University)

  • Matthieu Gérard

    (Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay)

Abstract

Genome-wide binding profiles for eight different chromatin remodellers in mouse embryonic stem (ES) cells are determined at single nucleosome resolution; each remodeller binds at specific nucleosome positions relative to the start of genes, and the same remodeller acts as a positive or negative regulator of transcription depending on the promoter chromatin organization and epigenetic marking of the gene it binds.

Suggested Citation

  • Maud de Dieuleveult & Kuangyu Yen & Isabelle Hmitou & Arnaud Depaux & Fayçal Boussouar & Daria Bou Dargham & Sylvie Jounier & Hélène Humbertclaude & Florence Ribierre & Céline Baulard & Nina P. Farrel, 2016. "Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells," Nature, Nature, vol. 530(7588), pages 113-116, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7588:d:10.1038_nature16505
    DOI: 10.1038/nature16505
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    Cited by:

    1. Mariko Sasaki & Daiki Kato & Karin Murakami & Hiroshi Yoshida & Shohei Takase & Tsuguteru Otsubo & Hideaki Ogiwara, 2024. "Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Gang Ren & Wai Lim Ku & Guangzhe Ge & Jackson A. Hoffman & Jee Youn Kang & Qingsong Tang & Kairong Cui & Yong He & Yukun Guan & Bin Gao & Chengyu Liu & Trevor K. Archer & Keji Zhao, 2024. "Acute depletion of BRG1 reveals its primary function as an activator of transcription," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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