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An essential receptor for adeno-associated virus infection

Author

Listed:
  • S. Pillay

    (Stanford University School of Medicine)

  • N. L. Meyer

    (School of Medicine, Oregon Health & Science University)

  • A. S. Puschnik

    (Stanford University School of Medicine)

  • O. Davulcu

    (School of Medicine, Oregon Health & Science University)

  • J. Diep

    (Stanford University School of Medicine)

  • Y. Ishikawa

    (School of Medicine, Oregon Health & Science University
    Shriners Hospital for Children)

  • L. T. Jae

    (Netherlands Cancer Institute)

  • J. E. Wosen

    (Stanford University School of Medicine)

  • C. M. Nagamine

    (Stanford University School of Medicine)

  • M. S. Chapman

    (School of Medicine, Oregon Health & Science University)

  • J. E. Carette

    (Stanford University School of Medicine)

Abstract

An adeno-associated virus (AAV) receptor protein essential for AAV2 entry into cells is identified; AAV receptor binds directly to the virus, and its ablation renders a diverse range of mammalian cell types and mice resistant to infection by AAV of multiple serotypes.

Suggested Citation

  • S. Pillay & N. L. Meyer & A. S. Puschnik & O. Davulcu & J. Diep & Y. Ishikawa & L. T. Jae & J. E. Wosen & C. M. Nagamine & M. S. Chapman & J. E. Carette, 2016. "An essential receptor for adeno-associated virus infection," Nature, Nature, vol. 530(7588), pages 108-112, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7588:d:10.1038_nature16465
    DOI: 10.1038/nature16465
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    Cited by:

    1. Zengpeng Han & Nengsong Luo & Wenyu Ma & Xiaodong Liu & Yuxiang Cai & Jiaxin Kou & Jie Wang & Lei Li & Siqi Peng & Zihong Xu & Wen Zhang & Yuxiang Qiu & Yang Wu & Chaohui Ye & Kunzhang Lin & Fuqiang X, 2023. "AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Ai Vu Hong & Laurence Suel & Eva Petat & Auriane Dubois & Pierre-Romain Le Brun & Nicolas Guerchet & Philippe Veron & Jérôme Poupiot & Isabelle Richard, 2024. "An engineered AAV targeting integrin alpha V beta 6 presents improved myotropism across species," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Timothy F. Shay & Seongmin Jang & Tyler J. Brittain & Xinhong Chen & Beth Walker & Claire Tebbutt & Yujie Fan & Damien A. Wolfe & Cynthia M. Arokiaraj & Erin E. Sullivan & Xiaozhe Ding & Ting-Yu Wang , 2024. "Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Mercedes Barzi & Tong Chen & Trevor J. Gonzalez & Francis P. Pankowicz & Seh Hoon Oh & Helen L. Streff & Alan Rosales & Yunhan Ma & Sabrina Collias & Sarah E. Woodfield & Anna Mae Diehl & Sanjeev A. V, 2024. "A humanized mouse model for adeno-associated viral gene therapy," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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