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Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia

Author

Listed:
  • Nicola B. Hamilton

    (Physiology & Pharmacology, University College London)

  • Karolina Kolodziejczyk

    (Physiology & Pharmacology, University College London
    †Present address: Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.)

  • Eleni Kougioumtzidou

    (Physiology & Pharmacology, University College London)

  • David Attwell

    (Physiology & Pharmacology, University College London)

Abstract

Ischaemia damages nerve myelin by depriving neurons and their myelinating oligodendrocytes of oxygen and glucose; here it is shown that ischaemic damage is caused through the H+-dependent activation of TRPA1 channels, and not via glutamate receptors of the NMDA type, as previously thought, providing a new mechanism and promising therapeutic targets for diseases as diverse and prevalent as cerebral palsy, spinal cord injury, stroke and multiple sclerosis.

Suggested Citation

  • Nicola B. Hamilton & Karolina Kolodziejczyk & Eleni Kougioumtzidou & David Attwell, 2016. "Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia," Nature, Nature, vol. 529(7587), pages 523-527, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7587:d:10.1038_nature16519
    DOI: 10.1038/nature16519
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    Cited by:

    1. Xiaoning Wang & Yangyang Sun & Qian Wang & Fengying Liu & Weijie Yang & Xin Sui & Jun Yang & Minmin Zhang & Shuai Wang & Zhenyu Xiao & Yuan Luo & Yongan Wang & Tong Zhu, 2022. "Potential Common Mechanisms of Cytotoxicity Induced by Amide Herbicides via TRPA1 Channel Activation," IJERPH, MDPI, vol. 19(13), pages 1-18, June.
    2. Frederic Fiore & Khaleel Alhalaseh & Ram R. Dereddi & Felipe Bodaleo Torres & Ilknur Çoban & Ali Harb & Amit Agarwal, 2023. "Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-25, December.

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