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Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

Author

Listed:
  • Larry L. Luchsinger

    (Columbia Center for Translational Immunology, Columbia University Medical Center
    Columbia University Medical Center)

  • Mariana Justino de Almeida

    (Columbia Center for Translational Immunology, Columbia University Medical Center
    Columbia University Medical Center)

  • David J. Corrigan

    (Columbia Center for Translational Immunology, Columbia University Medical Center
    Columbia University Medical Center)

  • Melanie Mumau

    (Columbia Center for Translational Immunology, Columbia University Medical Center
    Columbia University Medical Center)

  • Hans-Willem Snoeck

    (Columbia Center for Translational Immunology, Columbia University Medical Center
    Columbia University Medical Center
    Columbia University Medical Center)

Abstract

The role of mitochondria in haematopoietic stem-cell maintenance has not been examined in detail; here mitofusin 2, which modulates mitochondrial fusion and tethering of endoplasmic reticulum to the mitochondria, is shown to be necessary for the maintenance of haematopoietic stem cells with extensive lymphoid potential.

Suggested Citation

  • Larry L. Luchsinger & Mariana Justino de Almeida & David J. Corrigan & Melanie Mumau & Hans-Willem Snoeck, 2016. "Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential," Nature, Nature, vol. 529(7587), pages 528-531, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7587:d:10.1038_nature16500
    DOI: 10.1038/nature16500
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    Cited by:

    1. Mohammad Naimul Islam & Galina A. Gusarova & Shonit R. Das & Li Li & Eiji Monma & Murari Anjaneyulu & Liberty Mthunzi & Sadiqa K. Quadri & Edward Owusu-Ansah & Sunita Bhattacharya & Jahar Bhattacharya, 2022. "The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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