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Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

Author

Listed:
  • Chong T. Luo

    (Immunology Program, Memorial Sloan Kettering Cancer Center
    Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center)

  • Will Liao

    (New York Genome Center)

  • Saida Dadi

    (Immunology Program, Memorial Sloan Kettering Cancer Center)

  • Ahmed Toure

    (Immunology Program, Memorial Sloan Kettering Cancer Center)

  • Ming O. Li

    (Immunology Program, Memorial Sloan Kettering Cancer Center)

Abstract

The transcription factor Foxo1 is shown to be involved in the determination of distinct subsets of regulatory T (Treg) cells, and the differentiation of activated phenotype Treg cells is associated with the repression of the Foxo1-dependent transcriptional program; constitutively active Foxo1 expression triggers depletion of activated Treg cells in peripheral tissues and leads to CD8 T-cell-mediated autoimmunity and anti-tumour immunity.

Suggested Citation

  • Chong T. Luo & Will Liao & Saida Dadi & Ahmed Toure & Ming O. Li, 2016. "Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity," Nature, Nature, vol. 529(7587), pages 532-536, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7587:d:10.1038_nature16486
    DOI: 10.1038/nature16486
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    Cited by:

    1. Lizhen Zhu & Geng Li & Zhixin Liang & Tuan Qi & Kui Deng & Jiancheng Yu & Yue Peng & Jusheng Zheng & Yan Song & Xing Chang, 2023. "Microbiota-assisted iron uptake promotes immune tolerance in the intestine," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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