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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Author

Listed:
  • Denise Martinez-Zapien

    (Equipe labellisée Ligue, Biotechnologie et signalisation cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant)

  • Francesc Xavier Ruiz

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg)

  • Juline Poirson

    (Equipe labellisée Ligue, Biotechnologie et signalisation cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant)

  • André Mitschler

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg)

  • Juan Ramirez

    (Equipe labellisée Ligue, Biotechnologie et signalisation cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant)

  • Anne Forster

    (Equipe labellisée Ligue, Biotechnologie et signalisation cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant)

  • Alexandra Cousido-Siah

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg)

  • Murielle Masson

    (Equipe labellisée Ligue, Biotechnologie et signalisation cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant)

  • Scott Vande Pol

    (University of Virginia)

  • Alberto Podjarny

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg)

  • Gilles Travé

    (Equipe labellisée Ligue, Biotechnologie et signalisation cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant)

  • Katia Zanier

    (Equipe labellisée Ligue, Biotechnologie et signalisation cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant)

Abstract

WebStructural details of how oncogenic human papilloma viruses induce cancer by targeting the tumour suppressor p53 for ubiquitin-mediated degradation.

Suggested Citation

  • Denise Martinez-Zapien & Francesc Xavier Ruiz & Juline Poirson & André Mitschler & Juan Ramirez & Anne Forster & Alexandra Cousido-Siah & Murielle Masson & Scott Vande Pol & Alberto Podjarny & Gilles , 2016. "Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53," Nature, Nature, vol. 529(7587), pages 541-545, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7587:d:10.1038_nature16481
    DOI: 10.1038/nature16481
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    Cited by:

    1. John C. K. Wang & Hannah T. Baddock & Amirhossein Mafi & Ian T. Foe & Matthew Bratkowski & Ting-Yu Lin & Zena D. Jensvold & Magdalena Preciado López & David Stokoe & Dan Eaton & Qi Hao & Aaron H. Nile, 2024. "Structure of the p53 degradation complex from HPV16," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Gergo Gogl & Boglarka Zambo & Camille Kostmann & Alexandra Cousido-Siah & Bastien Morlet & Fabien Durbesson & Luc Negroni & Pascal Eberling & Pau Jané & Yves Nominé & Andras Zeke & Søren Østergaard & , 2022. "Quantitative fragmentomics allow affinity mapping of interactomes," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Zhen Wang & Fengying Fan & Zhihai Li & Fei Ye & Qingxia Wang & Rongchao Gao & Jiaxuan Qiu & Yixin Lv & Min Lin & Wenwen Xu & Cheng Luo & Xuekui Yu, 2024. "Structural insights into the functional mechanism of the ubiquitin ligase E6AP," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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