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The domestication of Cas9

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  • Fyodor Urnov

    (Fyodor Urnov is at Sangamo BioSciences, Richmond, California 94804, USA.)

Abstract

The enzyme Cas9 is used in genome editing to cut selected DNA sequences, but it also creates breaks at off-target sites. Protein engineering has now been used to make Cas9 enzymes that have minimal off-target effects. See Article p.490

Suggested Citation

  • Fyodor Urnov, 2016. "The domestication of Cas9," Nature, Nature, vol. 529(7587), pages 468-469, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7587:d:10.1038_529468a
    DOI: 10.1038/529468a
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