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Reparative inflammation takes charge of tissue regeneration

Author

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  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, Moores Cancer Center, University of California San Diego School of Medicine)

  • Hans Clevers

    (Princess Máxima Center and Hubrecht Institute
    University Medical Center Utrecht)

Abstract

Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.

Suggested Citation

  • Michael Karin & Hans Clevers, 2016. "Reparative inflammation takes charge of tissue regeneration," Nature, Nature, vol. 529(7586), pages 307-315, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature17039
    DOI: 10.1038/nature17039
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    Cited by:

    1. Diana Boraschi & Dongjie Li & Yang Li & Paola Italiani, 2021. "In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials," IJERPH, MDPI, vol. 18(22), pages 1-16, November.

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