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Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

Author

Listed:
  • Shaokun Shu

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Charles Y. Lin

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Housheng Hansen He

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School
    Dana-Farber Cancer Institute, Harvard School of Public Health
    Princess Margaret Cancer Center/University Health Network)

  • Robert M. Witwicki

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Doris P. Tabassum

    (Dana-Farber Cancer Institute)

  • Justin M. Roberts

    (Dana-Farber Cancer Institute)

  • Michalina Janiszewska

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Sung Jin Huh

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Yi Liang

    (Princess Margaret Cancer Center/University Health Network)

  • Jeremy Ryan

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Ernest Doherty

    (Dana-Farber Cancer Institute
    Harvard University)

  • Hisham Mohammed

    (Cancer Research UK, Cambridge Institute, University of Cambridge)

  • Hao Guo

    (Dana-Farber Cancer Institute, Harvard School of Public Health)

  • Daniel G. Stover

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Muhammad B. Ekram

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Guillermo Peluffo

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Jonathan Brown

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Clive D’Santos

    (Cancer Research UK, Cambridge Institute, University of Cambridge)

  • Ian E. Krop

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Deborah Dillon

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Michael McKeown

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Christopher Ott

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Jun Qi

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Min Ni

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Prakash K. Rao

    (Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • Melissa Duarte

    (Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • Shwu-Yuan Wu

    (Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center)

  • Cheng-Ming Chiang

    (Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center)

  • Lars Anders

    (Whitehead Institute for Biomedical Research)

  • Richard A. Young

    (Whitehead Institute for Biomedical Research)

  • Eric P. Winer

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Antony Letai

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • William T. Barry

    (Brigham and Women’s Hospital, Harvard Medical School
    Dana-Farber Cancer Institute, Harvard School of Public Health)

  • Jason S. Carroll

    (Cancer Research UK, Cambridge Institute, University of Cambridge)

  • Henry W. Long

    (Dana-Farber Cancer Institute
    Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • Myles Brown

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School
    Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • X. Shirley Liu

    (Dana-Farber Cancer Institute, Harvard School of Public Health
    Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
    Broad Institute)

  • Clifford A. Meyer

    (Dana-Farber Cancer Institute, Harvard School of Public Health)

  • James E. Bradner

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School
    Broad Institute)

  • Kornelia Polyak

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School
    Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
    Broad Institute)

Abstract

BET inhibitors that target bromodomain chromatin readers such as BRD4 are being explored as potential therapeutics in cancer; here triple-negative breast cancer cell lines are shown to respond to BET inhibitors and resistance seems to be associated with transcriptional changes rather than drug efflux and mutations, opening potential avenues to improve clinical responses to BET inhibitors.

Suggested Citation

  • Shaokun Shu & Charles Y. Lin & Housheng Hansen He & Robert M. Witwicki & Doris P. Tabassum & Justin M. Roberts & Michalina Janiszewska & Sung Jin Huh & Yi Liang & Jeremy Ryan & Ernest Doherty & Hisham, 2016. "Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer," Nature, Nature, vol. 529(7586), pages 413-417, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature16508
    DOI: 10.1038/nature16508
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    Cited by:

    1. Andrew J. Tao & Jiewei Jiang & Gillian E. Gadbois & Pavitra Goyal & Bridget T. Boyle & Elizabeth J. Mumby & Samuel A. Myers & Justin G. English & Fleur M. Ferguson, 2023. "A biotin targeting chimera (BioTAC) system to map small molecule interactomes in situ," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Di Yu & Yingying Liang & Claudia Kim & Anbalagan Jaganathan & Donglei Ji & Xinye Han & Xuelan Yang & Yanjie Jia & Ruirui Gu & Chunyu Wang & Qiang Zhang & Ka Lung Cheung & Ming-Ming Zhou & Lei Zeng, 2023. "Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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