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Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

Author

Listed:
  • Alistair N. Boettiger

    (Howard Hughes Medical Institute, Harvard University)

  • Bogdan Bintu

    (Howard Hughes Medical Institute, Harvard University)

  • Jeffrey R. Moffitt

    (Howard Hughes Medical Institute, Harvard University)

  • Siyuan Wang

    (Howard Hughes Medical Institute, Harvard University)

  • Brian J. Beliveau

    (Harvard Medical School)

  • Geoffrey Fudenberg

    (Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT))

  • Maxim Imakaev

    (Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT))

  • Leonid A. Mirny

    (Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT))

  • Chao-ting Wu

    (Harvard Medical School)

  • Xiaowei Zhuang

    (Howard Hughes Medical Institute, Harvard University)

Abstract

Using super-resolution imaging to directly observe the three-dimensional organization of Drosophila chromatin at a scale spanning sizes from individual genes to entire gene regulatory domains, the authors find that transcriptionally active, inactive and Polycomb-repressed chromatin states each have a distinct spatial organisation.

Suggested Citation

  • Alistair N. Boettiger & Bogdan Bintu & Jeffrey R. Moffitt & Siyuan Wang & Brian J. Beliveau & Geoffrey Fudenberg & Maxim Imakaev & Leonid A. Mirny & Chao-ting Wu & Xiaowei Zhuang, 2016. "Super-resolution imaging reveals distinct chromatin folding for different epigenetic states," Nature, Nature, vol. 529(7586), pages 418-422, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature16496
    DOI: 10.1038/nature16496
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    Citations

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    Cited by:

    1. Gerard Llimos & Vincent Gardeux & Ute Koch & Judith F. Kribelbauer & Antonina Hafner & Daniel Alpern & Joern Pezoldt & Maria Litovchenko & Julie Russeil & Riccardo Dainese & Riccardo Moia & Abdurraouf, 2022. "A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Takeo Kubota & Kazuki Mochizuki, 2016. "Epigenetic Effect of Environmental Factors on Autism Spectrum Disorders," IJERPH, MDPI, vol. 13(5), pages 1-12, May.
    3. Allison P. Siegenfeld & Shelby A. Roseman & Heejin Roh & Nicholas Z. Lue & Corin C. Wagen & Eric Zhou & Sarah E. Johnstone & Martin J. Aryee & Brian B. Liau, 2022. "Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Sangram Kadam & Kiran Kumari & Vinoth Manivannan & Shuvadip Dutta & Mithun K. Mitra & Ranjith Padinhateeri, 2023. "Predicting scale-dependent chromatin polymer properties from systematic coarse-graining," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Ting Peng & Yingping Hou & Haowei Meng & Yong Cao & Xiaotian Wang & Lumeng Jia & Qing Chen & Yang Zheng & Yujie Sun & Hebing Chen & Tingting Li & Cheng Li, 2023. "Mapping nucleolus-associated chromatin interactions using nucleolus Hi-C reveals pattern of heterochromatin interactions," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Surya K Ghosh & Daniel Jost, 2018. "How epigenome drives chromatin folding and dynamics, insights from efficient coarse-grained models of chromosomes," PLOS Computational Biology, Public Library of Science, vol. 14(5), pages 1-26, May.
    7. Markus Götz & Olivier Messina & Sergio Espinola & Jean-Bernard Fiche & Marcelo Nollmann, 2022. "Multiple parameters shape the 3D chromatin structure of single nuclei at the doc locus in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Ana Mota & Szymon Berezicki & Erik Wernersson & Luuk Harbers & Xiaoze Li-Wang & Katarina Gradin & Christiane Peuckert & Nicola Crosetto & Magda Bienko, 2022. "FRET-FISH probes chromatin compaction at individual genomic loci in single cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    9. Mattia Conte & Ehsan Irani & Andrea M. Chiariello & Alex Abraham & Simona Bianco & Andrea Esposito & Mario Nicodemi, 2022. "Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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