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Divergent clonal selection dominates medulloblastoma at recurrence

Author

Listed:
  • A. Sorana Morrissy

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Livia Garzia

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • David J. H. Shih

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto)

  • Scott Zuyderduyn

    (The Donnelly Centre, University of Toronto)

  • Xi Huang

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children)

  • Patryk Skowron

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto)

  • Marc Remke

    (Hematology, and Clinical Immunology, University Hospital Düsseldorf)

  • Florence M. G. Cavalli

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Vijay Ramaswamy

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto
    The Hospital for Sick Children)

  • Patricia E. Lindsay

    (University of Toronto
    Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network)

  • Salomeh Jelveh

    (Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network)

  • Laura K. Donovan

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Xin Wang

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto)

  • Betty Luu

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Kory Zayne

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Yisu Li

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Chelsea Mayoh

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Nina Thiessen

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Eloi Mercier

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Karen L. Mungall

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Yusanne Ma

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Kane Tse

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Thomas Zeng

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Karey Shumansky

    (BC Cancer Agency)

  • Andrew J. L. Roth

    (BC Cancer Agency)

  • Sohrab Shah

    (BC Cancer Agency)

  • Hamza Farooq

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Noriyuki Kijima

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Borja L. Holgado

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • John J. Y. Lee

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto)

  • Stuart Matan-Lithwick

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Jessica Liu

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Stephen C. Mack

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    Center for Stem Cell & Regenerative Medicine, Cleveland Clinic Foundation)

  • Alex Manno

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • K. A. Michealraj

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Carolina Nor

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • John Peacock

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto)

  • Lei Qin

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Juri Reimand

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    The Donnelly Centre, University of Toronto)

  • Adi Rolider

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Yuan Y. Thompson

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto)

  • Xiaochong Wu

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Trevor Pugh

    (Clinical Genomics Research Program, Princess Margaret Cancer Centre, University Health Network)

  • Adrian Ally

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Mikhail Bilenky

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Yaron S. N. Butterfield

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Rebecca Carlsen

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Young Cheng

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Eric Chuah

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Richard D. Corbett

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Noreen Dhalla

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • An He

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Darlene Lee

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Haiyan I. Li

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • William Long

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Michael Mayo

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Patrick Plettner

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Jenny Q. Qian

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Jacqueline E. Schein

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Angela Tam

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Tina Wong

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Inanc Birol

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
    University of British Columbia
    School of Computing Science, Simon Fraser University)

  • Yongjun Zhao

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Claudia C. Faria

    (Centro Hospitalar Lisboa Norte, Hospital de Santa Maria)

  • José Pimentel

    (Divison of Pathology, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria)

  • Sofia Nunes

    (Unidade de Neuro-Oncologia Pediátrica, Instituto Português de Oncologia de Lisboa Francisco Gentil)

  • Tarek Shalaby

    (University Children’s Hospital of Zurich)

  • Michael Grotzer

    (University Children’s Hospital of Zurich)

  • Ian F. Pollack

    (University of Pittsburgh School of Medicine)

  • Ronald L. Hamilton

    (University of Pittsburgh School of Medicine)

  • Xiao-Nan Li

    (Brain Tumor Program, Baylor College of Medicine)

  • Anne E. Bendel

    (Pediatric Hematology-Oncology, Children’s Hospitals and Clinics of Minnesota)

  • Daniel W. Fults

    (Clinical Neurosciences Center, University of Utah, Salt Lake City)

  • Andrew W. Walter

    (A I duPont Hospital for Children)

  • Toshihiro Kumabe

    (Kitasato University School of Medicine)

  • Teiji Tominaga

    (Tohoku University Graduate School of Medicine)

  • V. Peter Collins

    (University of Cambridge)

  • Yoon-Jae Cho

    (Neurology and Neurological Sciences, Stanford University School of Medicine)

  • Caitlin Hoffman

    (The Hospital for Sick Children)

  • David Lyden

    (Cell & Developmental Biology, Weill Medical College of Cornell University)

  • Jeffrey H. Wisoff

    (NYU Langone Medical Center)

  • James H. Garvin

    (Oncology, and Stem Cell Transplantation, Columbia University)

  • Duncan S. Stearns

    (Case Western Reserve)

  • Luca Massimi

    (Pediatric Neurosurgery, Catholic University Medical School)

  • Ulrich Schüller

    (Center for Neuropathology, Ludwig-Maximilians-Universität)

  • Jaroslav Sterba

    (School of Medicine, Masaryk University)

  • Karel Zitterbart

    (School of Medicine, Masaryk University)

  • Stephanie Puget

    (AP-HP, Necker-Enfants Malades Hospital, Université René Descartes)

  • Olivier Ayrault

    (Signaling in Development and Brain Tumors, CNRS UMR 3347 / INSERM U1021, Institut Curie)

  • Sandra E. Dunn

    (British Columbia Children’s Hospital)

  • Daniela P. C. Tirapelli

    (Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Brazil)

  • Carlos G. Carlotti

    (Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Brazil)

  • Helen Wheeler

    (Kolling Institute of Medical Research, The University of Sydney)

  • Andrew R. Hallahan

    (Queensland Children's Medical Research Institute, Children’s Health Queensland
    Children’s Health Queensland)

  • Wendy Ingram

    (Queensland Children's Medical Research Institute, Children’s Health Queensland
    UQ Child Health Research Centre, The University of Queensland)

  • Tobey J. MacDonald

    (Pediatric Neuro-Oncology Program, School of Medicine and Winship Cancer Institute, Emory University)

  • Jeffrey J. Olson

    (School of Medicine and Winship Cancer Institute, Emory University)

  • Erwin G. Van Meir

    (School of Medicine and Winship Cancer Institute, Emory University)

  • Ji-Yeoun Lee

    (Seoul National University Children’s Hospital)

  • Kyu-Chang Wang

    (Seoul National University Children’s Hospital)

  • Seung-Ki Kim

    (Seoul National University Children’s Hospital)

  • Byung-Kyu Cho

    (Seoul National University Children’s Hospital)

  • Torsten Pietsch

    (Institute for Neuropathology, University of Bonn D-53105)

  • Gudrun Fleischhack

    (Children’s University Hospital of Essen D-45147)

  • Stephan Tippelt

    (Children’s University Hospital of Essen D-45147)

  • Young Shin Ra

    (University of Ulsan, Asan Medical Center)

  • Simon Bailey

    (Northern Institute for Cancer Research, Newcastle University)

  • Janet C. Lindsey

    (Northern Institute for Cancer Research, Newcastle University)

  • Steven C. Clifford

    (Northern Institute for Cancer Research, Newcastle University)

  • Charles G. Eberhart

    (Ophthalmology and Oncology, John Hopkins University School of Medicine)

  • Michael K. Cooper

    (Department of Neurology)

  • Roger J. Packer

    (Children’s National Medical Center)

  • Maura Massimino

    (Fondazione IRCCS Istituto Nazionale Tumori)

  • Maria Luisa Garre

    (U.O. Neurochirurgia, Istituto Giannina Gaslini)

  • Ute Bartels

    (The Hospital for Sick Children)

  • Uri Tabori

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    The Hospital for Sick Children)

  • Cynthia E. Hawkins

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    The Hospital for Sick Children)

  • Peter Dirks

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    The Hospital for Sick Children)

  • Eric Bouffet

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    The Hospital for Sick Children)

  • James T. Rutka

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto
    The Hospital for Sick Children)

  • Robert J. Wechsler-Reya

    (Sanford-Burnham Medical Research Institute)

  • William A. Weiss

    (Neurology and Neurosurgery, University of California San Francisco)

  • Lara S. Collier

    (School of Pharmacology, University of Wisconsin)

  • Adam J. Dupuy

    (Molecular & Cellular Biology Program, University of Iowa, Iowa City)

  • Andrey Korshunov

    (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ))

  • David T. W. Jones

    (German Cancer Research Center (DKFZ))

  • Marcel Kool

    (German Cancer Research Center (DKFZ))

  • Paul A. Northcott

    (German Cancer Research Center (DKFZ))

  • Stefan M. Pfister

    (German Cancer Research Center (DKFZ)
    University Hospital Heidelberg)

  • David A. Largaespada

    (Masonic Cancer Center, University of Minnesota)

  • Andrew J. Mungall

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Richard A. Moore

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency)

  • Nada Jabado

    (McGill University)

  • Gary D. Bader

    (The Donnelly Centre, University of Toronto
    University of Toronto)

  • Steven J. M. Jones

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
    University of British Columbia
    Simon Fraser University)

  • David Malkin

    (The Hospital for Sick Children
    University of Toronto)

  • Marco A. Marra

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
    University of British Columbia)

  • Michael D. Taylor

    (Developmental & Stem Cell Biology Program, The Hospital for Sick Children
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
    University of Toronto
    The Hospital for Sick Children)

Abstract

The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon–driven, functional genomic mouse model of medulloblastoma with ‘humanized’ in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (

Suggested Citation

  • A. Sorana Morrissy & Livia Garzia & David J. H. Shih & Scott Zuyderduyn & Xi Huang & Patryk Skowron & Marc Remke & Florence M. G. Cavalli & Vijay Ramaswamy & Patricia E. Lindsay & Salomeh Jelveh & Lau, 2016. "Divergent clonal selection dominates medulloblastoma at recurrence," Nature, Nature, vol. 529(7586), pages 351-357, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature16478
    DOI: 10.1038/nature16478
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    Cited by:

    1. Zaili Luo & Dazhuan Xin & Yunfei Liao & Kalen Berry & Sean Ogurek & Feng Zhang & Liguo Zhang & Chuntao Zhao & Rohit Rao & Xinran Dong & Hao Li & Jianzhong Yu & Yifeng Lin & Guoying Huang & Lingli Xu &, 2023. "Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Oliver J. Mainwaring & Holger Weishaupt & Miao Zhao & Gabriela Rosén & Anna Borgenvik & Laura Breinschmid & Annemieke D. Verbaan & Stacey Richardson & Dean Thompson & Steven C. Clifford & Rebecca M. H, 2023. "ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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