IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v529y2016i7585d10.1038_nature16498.html
   My bibliography  Save this article

FOXO1 couples metabolic activity and growth state in the vascular endothelium

Author

Listed:
  • Kerstin Wilhelm

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Katharina Happel

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Guy Eelen

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB)

  • Sandra Schoors

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB)

  • Mark F. Oellerich

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Radiance Lim

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Barbara Zimmermann

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Irene M. Aspalter

    (Vascular Biology Laboratory, London Research Institute, Cancer Research UK)

  • Claudio A. Franco

    (Vascular Morphogenesis Laboratory, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa)

  • Thomas Boettger

    (Max Planck Institute for Heart and Lung Research)

  • Thomas Braun

    (Max Planck Institute for Heart and Lung Research)

  • Marcus Fruttiger

    (UCL Institute of Ophthalmology, University College London)

  • Klaus Rajewsky

    (Max Delbrück Center for Molecular Medicine (MDC))

  • Charles Keller

    (Children’s Cancer Therapy Development Institute)

  • Jens C. Brüning

    (Max Planck Institute for Metabolism Research, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University of Cologne)

  • Holger Gerhardt

    (Vascular Biology Laboratory, London Research Institute, Cancer Research UK
    Max Delbrück Center for Molecular Medicine (MDC)
    Vascular Patterning Laboratory, Vesalius Research Center, VIB and University of Leuven
    DZHK (German Center for Cardiovascular Research), partner site Berlin)

  • Peter Carmeliet

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB)

  • Michael Potente

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
    International Institute of Molecular and Cell Biology
    DZHK (German Center for Cardiovascular Research), partner site Frankfurt Rhine-Main)

Abstract

The transcription factor FOXO1 is identified as a crucial checkpoint of vascular growth, coupling the metabolic and proliferative activities of endothelial cells.

Suggested Citation

  • Kerstin Wilhelm & Katharina Happel & Guy Eelen & Sandra Schoors & Mark F. Oellerich & Radiance Lim & Barbara Zimmermann & Irene M. Aspalter & Claudio A. Franco & Thomas Boettger & Thomas Braun & Marcu, 2016. "FOXO1 couples metabolic activity and growth state in the vascular endothelium," Nature, Nature, vol. 529(7585), pages 216-220, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7585:d:10.1038_nature16498
    DOI: 10.1038/nature16498
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature16498
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature16498?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Balkrishna Chaube & Kathryn M. Citrin & Mahnaz Sahraei & Abhishek K. Singh & Diego Saenz Urturi & Wen Ding & Richard W. Pierce & Raaisa Raaisa & Rebecca Cardone & Richard Kibbey & Carlos Fernández-Her, 2023. "Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Jaco Selle & Katharina Dinger & Vanessa Jentgen & Daniela Zanetti & Johannes Will & Theodoros Georgomanolis & Christina Vohlen & Rebecca Wilke & Baktybek Kojonazarov & Oleksiy Klymenko & Jasmine Mohr , 2022. "Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    3. Haifeng Zhang & Busu Li & Qunhua Huang & Francesc López-Giráldez & Yoshiaki Tanaka & Qun Lin & Sameet Mehta & Guilin Wang & Morven Graham & Xinran Liu & In-Hyun Park & Anne Eichmann & Wang Min & Jenny, 2022. "Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:529:y:2016:i:7585:d:10.1038_nature16498. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.