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FOXO1 couples metabolic activity and growth state in the vascular endothelium

Author

Listed:
  • Kerstin Wilhelm

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Katharina Happel

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Guy Eelen

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB)

  • Sandra Schoors

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB)

  • Mark F. Oellerich

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Radiance Lim

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Barbara Zimmermann

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research)

  • Irene M. Aspalter

    (Vascular Biology Laboratory, London Research Institute, Cancer Research UK)

  • Claudio A. Franco

    (Vascular Morphogenesis Laboratory, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa)

  • Thomas Boettger

    (Max Planck Institute for Heart and Lung Research)

  • Thomas Braun

    (Max Planck Institute for Heart and Lung Research)

  • Marcus Fruttiger

    (UCL Institute of Ophthalmology, University College London)

  • Klaus Rajewsky

    (Max Delbrück Center for Molecular Medicine (MDC))

  • Charles Keller

    (Children’s Cancer Therapy Development Institute)

  • Jens C. Brüning

    (Max Planck Institute for Metabolism Research, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University of Cologne)

  • Holger Gerhardt

    (Vascular Biology Laboratory, London Research Institute, Cancer Research UK
    Max Delbrück Center for Molecular Medicine (MDC)
    Vascular Patterning Laboratory, Vesalius Research Center, VIB and University of Leuven
    DZHK (German Center for Cardiovascular Research), partner site Berlin)

  • Peter Carmeliet

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB)

  • Michael Potente

    (Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
    International Institute of Molecular and Cell Biology
    DZHK (German Center for Cardiovascular Research), partner site Frankfurt Rhine-Main)

Abstract

The transcription factor FOXO1 is identified as a crucial checkpoint of vascular growth, coupling the metabolic and proliferative activities of endothelial cells.

Suggested Citation

  • Kerstin Wilhelm & Katharina Happel & Guy Eelen & Sandra Schoors & Mark F. Oellerich & Radiance Lim & Barbara Zimmermann & Irene M. Aspalter & Claudio A. Franco & Thomas Boettger & Thomas Braun & Marcu, 2016. "FOXO1 couples metabolic activity and growth state in the vascular endothelium," Nature, Nature, vol. 529(7585), pages 216-220, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7585:d:10.1038_nature16498
    DOI: 10.1038/nature16498
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    Citations

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    Cited by:

    1. Haifeng Zhang & Busu Li & Qunhua Huang & Francesc López-Giráldez & Yoshiaki Tanaka & Qun Lin & Sameet Mehta & Guilin Wang & Morven Graham & Xinran Liu & In-Hyun Park & Anne Eichmann & Wang Min & Jenny, 2022. "Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Balkrishna Chaube & Kathryn M. Citrin & Mahnaz Sahraei & Abhishek K. Singh & Diego Saenz Urturi & Wen Ding & Richard W. Pierce & Raaisa Raaisa & Rebecca Cardone & Richard Kibbey & Carlos Fernández-Her, 2023. "Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Jaco Selle & Katharina Dinger & Vanessa Jentgen & Daniela Zanetti & Johannes Will & Theodoros Georgomanolis & Christina Vohlen & Rebecca Wilke & Baktybek Kojonazarov & Oleksiy Klymenko & Jasmine Mohr , 2022. "Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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