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Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Author

Listed:
  • Elaine E. Storm

    (Molecular Oncology, Genentech, Inc.)

  • Steffen Durinck

    (Molecular Biology, Genentech, Inc.)

  • Felipe de Sousa e Melo

    (Molecular Oncology, Genentech, Inc.)

  • Jarrod Tremayne

    (Translational Oncology, Genentech, Inc.)

  • Noelyn Kljavin

    (Molecular Oncology, Genentech, Inc.)

  • Christine Tan

    (Antibody Engineering, Genentech, Inc.)

  • Xiaofen Ye

    (Discovery Oncology, Genentech, Inc.)

  • Cecilia Chiu

    (Antibody Engineering, Genentech, Inc.)

  • Thinh Pham

    (Research Pathology, Genentech, Inc.)

  • Jo-Anne Hongo

    (Antibody Engineering, Genentech, Inc.)

  • Travis Bainbridge

    (Protein Chemistry, Genentech, Inc.)

  • Ron Firestein

    (Research Pathology, Genentech, Inc.)

  • Elizabeth Blackwood

    (Translational Oncology, Genentech, Inc.)

  • Ciara Metcalfe

    (Translational Oncology, Genentech, Inc.)

  • Eric W. Stawiski

    (Molecular Biology, Genentech, Inc.)

  • Robert L. Yauch

    (Discovery Oncology, Genentech, Inc.)

  • Yan Wu

    (Antibody Engineering, Genentech, Inc.)

  • Frederic J. de Sauvage

    (Molecular Oncology, Genentech, Inc.)

Abstract

Antibody-mediated inhibition of R-spondin-3 in colorectal tumours decreases tumour growth and promotes differentiation—these effects are associated with a decrease in expression of genes associated with stem-cell function.

Suggested Citation

  • Elaine E. Storm & Steffen Durinck & Felipe de Sousa e Melo & Jarrod Tremayne & Noelyn Kljavin & Christine Tan & Xiaofen Ye & Cecilia Chiu & Thinh Pham & Jo-Anne Hongo & Travis Bainbridge & Ron Fireste, 2016. "Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function," Nature, Nature, vol. 529(7584), pages 97-100, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7584:d:10.1038_nature16466
    DOI: 10.1038/nature16466
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