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A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

Author

Listed:
  • Joshua Tan

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    KEMRI-Wellcome Trust Research Programme, CGMRC
    University of Oxford, John Radcliffe Hospital)

  • Kathrin Pieper

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Luca Piccoli

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Abdirahman Abdi

    (KEMRI-Wellcome Trust Research Programme, CGMRC)

  • Mathilde Foglierini

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Roger Geiger

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    Institute for Microbiology, ETH Zurich)

  • Claire Maria Tully

    (KEMRI-Wellcome Trust Research Programme, CGMRC)

  • David Jarrossay

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Francis Maina Ndungu

    (KEMRI-Wellcome Trust Research Programme, CGMRC)

  • Juliana Wambua

    (KEMRI-Wellcome Trust Research Programme, CGMRC)

  • Philip Bejon

    (KEMRI-Wellcome Trust Research Programme, CGMRC
    University of Oxford, John Radcliffe Hospital)

  • Chiara Silacci Fregni

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Blanca Fernandez-Rodriguez

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Sonia Barbieri

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Siro Bianchi

    (Humabs BioMed SA)

  • Kevin Marsh

    (KEMRI-Wellcome Trust Research Programme, CGMRC
    University of Oxford, John Radcliffe Hospital)

  • Vandana Thathy

    (KEMRI-Wellcome Trust Research Programme, CGMRC)

  • Davide Corti

    (Humabs BioMed SA)

  • Federica Sallusto

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Peter Bull

    (KEMRI-Wellcome Trust Research Programme, CGMRC
    University of Oxford, John Radcliffe Hospital)

  • Antonio Lanzavecchia

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    Institute for Microbiology, ETH Zurich)

Abstract

Monoclonal antibodies with broad reactivity against antigens on the parasite that causes malaria, Plasmodium falciparum, are isolated from two subjects and are found to have an unusual insertion of an immunoglobulin-like domain from a different chromosome, illustrating a new mechanism of antibody diversification.

Suggested Citation

  • Joshua Tan & Kathrin Pieper & Luca Piccoli & Abdirahman Abdi & Mathilde Foglierini & Roger Geiger & Claire Maria Tully & David Jarrossay & Francis Maina Ndungu & Juliana Wambua & Philip Bejon & Chiara, 2016. "A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens," Nature, Nature, vol. 529(7584), pages 105-109, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7584:d:10.1038_nature16450
    DOI: 10.1038/nature16450
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