IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v529y2016i7584d10.1038_nature16187.html
   My bibliography  Save this article

Autophagy maintains stemness by preventing senescence

Author

Listed:
  • Laura García-Prat

    (Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED))

  • Marta Martínez-Vicente

    (Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute-CIBERNED)

  • Eusebio Perdiguero

    (Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED))

  • Laura Ortet

    (Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED))

  • Javier Rodríguez-Ubreva

    (Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat)

  • Elena Rebollo

    (Advanced Fluorescence Microscopy Unit, Molecular Biology Institute of Barcelona (IBMB-CSIC))

  • Vanessa Ruiz-Bonilla

    (Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED))

  • Susana Gutarra

    (Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED))

  • Esteban Ballestar

    (Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat)

  • Antonio L. Serrano

    (Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED))

  • Marco Sandri

    (University of Padova
    Telethon Institute of Genetics and Medicine (TIGEM))

  • Pura Muñoz-Cánoves

    (Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)
    ICREA)

Abstract

The regenerative properties of muscle stem cells decline with age as the stem cells enter an irreversible state of senescence; a study of mouse muscle stem cells reveals that entry into senescence is an autophagy-dependent process and promoting autophagy in old satellite cells can reverse senescence and restore their regenerative properties in an injury model.

Suggested Citation

  • Laura García-Prat & Marta Martínez-Vicente & Eusebio Perdiguero & Laura Ortet & Javier Rodríguez-Ubreva & Elena Rebollo & Vanessa Ruiz-Bonilla & Susana Gutarra & Esteban Ballestar & Antonio L. Serrano, 2016. "Autophagy maintains stemness by preventing senescence," Nature, Nature, vol. 529(7584), pages 37-42, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7584:d:10.1038_nature16187
    DOI: 10.1038/nature16187
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature16187
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature16187?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:529:y:2016:i:7584:d:10.1038_nature16187. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.