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Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Author

Listed:
  • Caroline A. Lindemans

    (Memorial Sloan Kettering Cancer Center
    University Medical Center Utrecht)

  • Marco Calafiore

    (Memorial Sloan Kettering Cancer Center)

  • Anna M. Mertelsmann

    (Memorial Sloan Kettering Cancer Center)

  • Margaret H. O’Connor

    (Memorial Sloan Kettering Cancer Center)

  • Jarrod A. Dudakov

    (Memorial Sloan Kettering Cancer Center
    Monash University)

  • Robert R. Jenq

    (Memorial Sloan Kettering Cancer Center
    Weill Cornell Medicine)

  • Enrico Velardi

    (Memorial Sloan Kettering Cancer Center)

  • Lauren F. Young

    (Memorial Sloan Kettering Cancer Center)

  • Odette M. Smith

    (Memorial Sloan Kettering Cancer Center)

  • Gillian Lawrence

    (Memorial Sloan Kettering Cancer Center)

  • Juliet A. Ivanov

    (Memorial Sloan Kettering Cancer Center)

  • Ya-Yuan Fu

    (Memorial Sloan Kettering Cancer Center)

  • Shuichiro Takashima

    (Memorial Sloan Kettering Cancer Center)

  • Guoqiang Hua

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Maria L. Martin

    (Memorial Sloan Kettering Cancer Center)

  • Kevin P. O’Rourke

    (Memorial Sloan Kettering Cancer Center)

  • Yuan-Hung Lo

    (Baylor College of Medicine)

  • Michal Mokry

    (University Medical Center Utrecht)

  • Monica Romera-Hernandez

    (Erasmus University Medical Center)

  • Tom Cupedo

    (Erasmus University Medical Center)

  • Lukas E. Dow

    (Weill Cornell Medicine)

  • Edward E. Nieuwenhuis

    (University Medical Center Utrecht)

  • Noah F. Shroyer

    (Baylor College of Medicine)

  • Chen Liu

    (Immunology and Laboratory Medicine, University of Florida College of Medicine)

  • Richard Kolesnick

    (Memorial Sloan Kettering Cancer Center)

  • Marcel R. M. van den Brink

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Alan M. Hanash

    (Memorial Sloan Kettering Cancer Center)

Abstract

Innate lymphoid cells increase the growth of mouse intestinal organoids via IL-22 production; recombinant IL-22 promotes growth of both mouse and human organoids, and promotes mouse intestinal stem cell (ISC) expansion and ISC-driven organoid growth via a STAT3-dependent pathway and independently of Paneth cells; IL-22 treatment in vivo enhances the recovery of ISCs from intestinal injury.

Suggested Citation

  • Caroline A. Lindemans & Marco Calafiore & Anna M. Mertelsmann & Margaret H. O’Connor & Jarrod A. Dudakov & Robert R. Jenq & Enrico Velardi & Lauren F. Young & Odette M. Smith & Gillian Lawrence & Juli, 2015. "Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration," Nature, Nature, vol. 528(7583), pages 560-564, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7583:d:10.1038_nature16460
    DOI: 10.1038/nature16460
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    Citations

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    Cited by:

    1. Jae Sung Lim & Eun Jae Jeon & Hye Sun Go & Hyung-Jin Kim & Kye Young Kim & Thi Quynh Trang Nguyen & Da Young Lee & Kyu Suk Kim & Federico Pietrocola & Seol Hee Hong & Shee Eun Lee & Kyoung-Shim Kim & , 2024. "Mucosal TLR5 activation controls healthspan and longevity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Haressh Sajiir & Sahar Keshvari & Kuan Yau Wong & Danielle J. Borg & Frederik J. Steyn & Christian Fercher & Karin Taylor & Breten Taylor & Ross T. Barnard & Alexandra Müller & Md Moniruzzaman & Grego, 2024. "Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Polychronis Pavlidis & Anastasia Tsakmaki & Eirini Pantazi & Katherine Li & Domenico Cozzetto & Jonathan Digby- Bell & Feifei Yang & Jonathan W. Lo & Elena Alberts & Ana Caroline Costa Sa & Umar Niazi, 2022. "Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Andrew K. Beppu & Juanjuan Zhao & Changfu Yao & Gianni Carraro & Edo Israely & Anna Lucia Coelho & Katherine Drake & Cory M. Hogaboam & William C. Parks & Jay K. Kolls & Barry R. Stripp, 2023. "Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Stephen J. Gaudino & Ankita Singh & Huakang Huang & Jyothi Padiadpu & Makheni Jean-Pierre & Cody Kempen & Tej Bahadur & Kiyoshi Shiomitsu & Richard Blumberg & Kenneth R. Shroyer & Semir Beyaz & Natali, 2024. "Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    6. Marco Calafiore & Ya-Yuan Fu & Paola Vinci & Viktor Arnhold & Winston Y. Chang & Suze A. Jansen & Anastasiya Egorova & Shuichiro Takashima & Jason Kuttiyara & Takahiro Ito & Jonathan Serody & Susumu N, 2023. "A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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