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Signal integration by Ca2+ regulates intestinal stem-cell activity

Author

Listed:
  • Hansong Deng

    (The Buck Institute for Research on Aging, 8001 Redwood Boulevard)

  • Akos A. Gerencser

    (The Buck Institute for Research on Aging, 8001 Redwood Boulevard)

  • Heinrich Jasper

    (The Buck Institute for Research on Aging, 8001 Redwood Boulevard)

Abstract

Drosophila intestinal stem cells (ISCs) respond to changes in diet, particularly L-glutamate levels, by modulating Ca2+ signalling to adapt their proliferation rate; furthermore, Ca2+ is shown to be central to the response of ISCs to a wide range of dietary and stress stimuli.

Suggested Citation

  • Hansong Deng & Akos A. Gerencser & Heinrich Jasper, 2015. "Signal integration by Ca2+ regulates intestinal stem-cell activity," Nature, Nature, vol. 528(7581), pages 212-217, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7581:d:10.1038_nature16170
    DOI: 10.1038/nature16170
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    Cited by:

    1. Peng Zhang & Stephen M. Pronovost & Marco Marchetti & Chenge Zhang & Xiaoyu Kang & Tahmineh Kandelouei & Christopher Li & Bruce A. Edgar, 2024. "Inter-cell type interactions that control JNK signaling in the Drosophila intestine," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Olga Kubrak & Anne F. Jørgensen & Takashi Koyama & Mette Lassen & Stanislav Nagy & Jacob Hald & Gianluca Mazzoni & Dennis Madsen & Jacob B. Hansen & Martin Røssel Larsen & Michael J. Texada & Jakob L., 2024. "LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Junjun Gao & Song Zhang & Pan Deng & Zhigang Wu & Bruno Lemaitre & Zongzhao Zhai & Zheng Guo, 2024. "Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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