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Molecular structures of unbound and transcribing RNA polymerase III

Author

Listed:
  • Niklas A. Hoffmann

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit)

  • Arjen J. Jakobi

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
    European Molecular Biology Laboratory (EMBL), Hamburg Unit)

  • María Moreno-Morcillo

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
    †Present addresses: Spanish National Cancer Research Centre (CNIO), Structural Biology and Biocomputing Programme, 28029 Madrid, Spain (M.M.-M.); Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A str, 30-387 Krakow, Poland (S.G.).)

  • Sebastian Glatt

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
    †Present addresses: Spanish National Cancer Research Centre (CNIO), Structural Biology and Biocomputing Programme, 28029 Madrid, Spain (M.M.-M.); Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A str, 30-387 Krakow, Poland (S.G.).)

  • Jan Kosinski

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit)

  • Wim J. H. Hagen

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit)

  • Carsten Sachse

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit)

  • Christoph W. Müller

    (European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit)

Abstract

RNA polymerase III (Pol III), the largest eukaryote polymerase yet characterized, transcribes structured small non-coding RNAs; here cryo-electron microscopy structures of budding yeast Pol III allow building of an atomic-level model of the complete 17-subunit complex, both unbound and while elongating RNA.

Suggested Citation

  • Niklas A. Hoffmann & Arjen J. Jakobi & María Moreno-Morcillo & Sebastian Glatt & Jan Kosinski & Wim J. H. Hagen & Carsten Sachse & Christoph W. Müller, 2015. "Molecular structures of unbound and transcribing RNA polymerase III," Nature, Nature, vol. 528(7581), pages 231-236, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7581:d:10.1038_nature16143
    DOI: 10.1038/nature16143
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    Citations

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    Cited by:

    1. Haifeng Hou & Yan Li & Mo Wang & Aijun Liu & Zishuo Yu & Ke Chen & Dan Zhao & Yanhui Xu, 2021. "Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Saurabh Mishra & Shaina H. Hasan & Rima M. Sakhawala & Shereen Chaudhry & Richard J. Maraia, 2021. "Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. Phong Quoc Nguyen & Sonia Huecas & Amna Asif-Laidin & Adrián Plaza-Pegueroles & Beatrice Capuzzi & Noé Palmic & Christine Conesa & Joël Acker & Juan Reguera & Pascale Lesage & Carlos Fernández-Tornero, 2023. "Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Joseph G. Beton & Thomas Mulvaney & Tristan Cragnolini & Maya Topf, 2024. "Cryo-EM structure and B-factor refinement with ensemble representation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Kevin Van Bortle & David P. Marciano & Qing Liu & Tristan Chou & Andrew M. Lipchik & Sanjay Gollapudi & Benjamin S. Geller & Emma Monte & Rohinton T. Kamakaka & Michael P. Snyder, 2022. "A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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