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FGF signalling regulates bone growth through autophagy

Author

Listed:
  • Laura Cinque

    (Telethon Institute of Genetics and Medicine (TIGEM)
    Dulbecco Telethon Institute)

  • Alison Forrester

    (Telethon Institute of Genetics and Medicine (TIGEM)
    Dulbecco Telethon Institute
    Medical Genetics Unit, Federico II University)

  • Rosa Bartolomeo

    (Telethon Institute of Genetics and Medicine (TIGEM)
    Dulbecco Telethon Institute)

  • Maria Svelto

    (Telethon Institute of Genetics and Medicine (TIGEM)
    Dulbecco Telethon Institute
    Medical Genetics Unit, Federico II University)

  • Rossella Venditti

    (Telethon Institute of Genetics and Medicine (TIGEM))

  • Sandro Montefusco

    (Telethon Institute of Genetics and Medicine (TIGEM))

  • Elena Polishchuk

    (Telethon Institute of Genetics and Medicine (TIGEM))

  • Edoardo Nusco

    (Telethon Institute of Genetics and Medicine (TIGEM))

  • Antonio Rossi

    (Biochemistry Unit, University of Pavia)

  • Diego L. Medina

    (Telethon Institute of Genetics and Medicine (TIGEM))

  • Roman Polishchuk

    (Telethon Institute of Genetics and Medicine (TIGEM))

  • Maria Antonietta De Matteis

    (Telethon Institute of Genetics and Medicine (TIGEM))

  • Carmine Settembre

    (Telethon Institute of Genetics and Medicine (TIGEM)
    Dulbecco Telethon Institute
    Medical Genetics Unit, Federico II University)

Abstract

During postnatal development in mice, the growth factor FGF18 induces autophagy in the chondrocyte cells of the growth plate to regulate the secretion of type II collagen, a process required for bone growth.

Suggested Citation

  • Laura Cinque & Alison Forrester & Rosa Bartolomeo & Maria Svelto & Rossella Venditti & Sandro Montefusco & Elena Polishchuk & Edoardo Nusco & Antonio Rossi & Diego L. Medina & Roman Polishchuk & Maria, 2015. "FGF signalling regulates bone growth through autophagy," Nature, Nature, vol. 528(7581), pages 272-275, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7581:d:10.1038_nature16063
    DOI: 10.1038/nature16063
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    Cited by:

    1. Chiara Parodi & Jonathan A Hardman & Giulia Allavena & Roberto Marotta & Tiziano Catelani & Marta Bertolini & Ralf Paus & Benedetto Grimaldi, 2018. "Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture," PLOS Biology, Public Library of Science, vol. 16(3), pages 1-22, March.
    2. Joanne Watson & Harriet R. Ferguson & Rosie M. Brady & Jennifer Ferguson & Paul Fullwood & Hanyi Mo & Katherine H. Bexley & David Knight & Gareth Howell & Jean-Marc Schwartz & Michael P. Smith & Chiar, 2022. "Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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