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Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

Author

Listed:
  • Marco Linari

    (Laboratory of Physiology, Università di Firenze
    Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, UdR Firenze)

  • Elisabetta Brunello

    (Laboratory of Physiology, Università di Firenze
    †Present address: Randall Division and BHF Centre for Research Excellence, King’s College London, London SE1 1UL, UK.)

  • Massimo Reconditi

    (Laboratory of Physiology, Università di Firenze
    Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, UdR Firenze)

  • Luca Fusi

    (King’s College London)

  • Marco Caremani

    (Laboratory of Physiology, Università di Firenze)

  • Theyencheri Narayanan

    (European Synchrotron Radiation Facility)

  • Gabriella Piazzesi

    (Laboratory of Physiology, Università di Firenze)

  • Vincenzo Lombardi

    (Laboratory of Physiology, Università di Firenze)

  • Malcolm Irving

    (King’s College London)

Abstract

It is widely accepted that contraction of skeletal muscle and the heart involves structural changes in actin-containing thin filaments to allow binding of myosin motors from neighbouring thick filaments, thus driving filament sliding; here, X-ray diffraction of single skeletal muscle cells reveals that this thin-filament mechanism can regulate muscle contraction against low load, but high-load contraction requires a second permissive step involving a structural change in the thick filament.

Suggested Citation

  • Marco Linari & Elisabetta Brunello & Massimo Reconditi & Luca Fusi & Marco Caremani & Theyencheri Narayanan & Gabriella Piazzesi & Vincenzo Lombardi & Malcolm Irving, 2015. "Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments," Nature, Nature, vol. 528(7581), pages 276-279, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7581:d:10.1038_nature15727
    DOI: 10.1038/nature15727
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    Cited by:

    1. Anthony L. Hessel & Nichlas M. Engels & Michel N. Kuehn & Devin Nissen & Rachel L. Sadler & Weikang Ma & Thomas C. Irving & Wolfgang A. Linke & Samantha P. Harris, 2024. "Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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