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Depletion of fat-resident Treg cells prevents age-associated insulin resistance

Author

Listed:
  • Sagar P. Bapat

    (Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies
    Gene Expression Laboratory, The Salk Institute for Biological Studies)

  • Jae Myoung Suh

    (Gene Expression Laboratory, The Salk Institute for Biological Studies
    Graduate School of Medical Science and Engineering)

  • Sungsoon Fang

    (Gene Expression Laboratory, The Salk Institute for Biological Studies
    College of Life Sciences, Sejong University)

  • Sihao Liu

    (Gene Expression Laboratory, The Salk Institute for Biological Studies)

  • Yang Zhang

    (Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies)

  • Albert Cheng

    (Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies)

  • Carmen Zhou

    (Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies)

  • Yuqiong Liang

    (Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies)

  • Mathias LeBlanc

    (Gene Expression Laboratory, The Salk Institute for Biological Studies)

  • Christopher Liddle

    (Storr Liver Centre, Westmead Millennium Institute, Sydney Medical School, University of Sydney)

  • Annette R. Atkins

    (Gene Expression Laboratory, The Salk Institute for Biological Studies)

  • Ruth T. Yu

    (Gene Expression Laboratory, The Salk Institute for Biological Studies)

  • Michael Downes

    (Gene Expression Laboratory, The Salk Institute for Biological Studies)

  • Ronald M. Evans

    (Gene Expression Laboratory, The Salk Institute for Biological Studies
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies)

  • Ye Zheng

    (Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies)

Abstract

Fat-resident regulatory T cells (fTreg cells) accumulate in adipose tissue of mice as a function of age, but not obesity; mice without fTreg cells are protected against age-associated insulin resistance, but remain susceptible to obesity-associated insulin resistance and metabolic disease, indicating different aetiologies of age-associated versus obesity-associated insulin resistance.

Suggested Citation

  • Sagar P. Bapat & Jae Myoung Suh & Sungsoon Fang & Sihao Liu & Yang Zhang & Albert Cheng & Carmen Zhou & Yuqiong Liang & Mathias LeBlanc & Christopher Liddle & Annette R. Atkins & Ruth T. Yu & Michael , 2015. "Depletion of fat-resident Treg cells prevents age-associated insulin resistance," Nature, Nature, vol. 528(7580), pages 137-141, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7580:d:10.1038_nature16151
    DOI: 10.1038/nature16151
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    Cited by:

    1. Aurélie Durand & Nelly Bonilla & Théo Level & Zoé Ginestet & Amélie Lombès & Vincent Guichard & Mathieu Germain & Sébastien Jacques & Franck Letourneur & Marcio Cruzeiro & Carmen Marchiol & Gilles Ren, 2024. "Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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