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Transcriptional regulators form diverse groups with context-dependent regulatory functions

Author

Listed:
  • Gerald Stampfel

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Tomáš Kazmar

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Olga Frank

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
    †Present address: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.)

  • Sebastian Wienerroither

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Franziska Reiter

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Alexander Stark

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

Abstract

A large-scale enhancer complementation assay assessing the activating or repressing contributions of over 800 Drosophila transcription factors and cofactors to combinatorial enhancer control reveals a more complex picture than expected, with many factors having diverse regulatory functions that depend on the enhancer context.

Suggested Citation

  • Gerald Stampfel & Tomáš Kazmar & Olga Frank & Sebastian Wienerroither & Franziska Reiter & Alexander Stark, 2015. "Transcriptional regulators form diverse groups with context-dependent regulatory functions," Nature, Nature, vol. 528(7580), pages 147-151, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7580:d:10.1038_nature15545
    DOI: 10.1038/nature15545
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    Cited by:

    1. Anat Kreimer & Tal Ashuach & Fumitaka Inoue & Alex Khodaverdian & Chengyu Deng & Nir Yosef & Nadav Ahituv, 2022. "Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Vincent Loubiere & Bernardo P. Almeida & Michaela Pagani & Alexander Stark, 2024. "Developmental and housekeeping transcriptional programs display distinct modes of enhancer-enhancer cooperativity in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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