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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

Author

Listed:
  • Xiaofeng Zheng

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center)

  • Julienne L. Carstens

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center)

  • Jiha Kim

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center)

  • Matthew Scheible

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center)

  • Judith Kaye

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center)

  • Hikaru Sugimoto

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center)

  • Chia-Chin Wu

    (University of Texas MD Anderson Cancer Center)

  • Valerie S. LeBleu

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center)

  • Raghu Kalluri

    (Metastasis Research Center, University of Texas MD Anderson Cancer Center
    Baylor College of Medicine
    Rice University)

Abstract

Deletion of Twist or Snail, two key transcription factors that induce epithelial-to-mesenchymal transition in a mouse model of pancreatic ductal adenocarcinoma leads to an increase in cell proliferation, and a greater sensitivity to the chemotherapeutic agent gemcitabine, with no effect on invasion or metastasis.

Suggested Citation

  • Xiaofeng Zheng & Julienne L. Carstens & Jiha Kim & Matthew Scheible & Judith Kaye & Hikaru Sugimoto & Chia-Chin Wu & Valerie S. LeBleu & Raghu Kalluri, 2015. "Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer," Nature, Nature, vol. 527(7579), pages 525-530, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7579:d:10.1038_nature16064
    DOI: 10.1038/nature16064
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    Cited by:

    1. Mariel C. Paul & Christian Schneeweis & Chiara Falcomatà & Chuan Shan & Daniel Rossmeisl & Stella Koutsouli & Christine Klement & Magdalena Zukowska & Sebastian A. Widholz & Moritz Jesinghaus & Konsta, 2023. "Non-canonical functions of SNAIL drive context-specific cancer progression," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Ankur Chakravarthy & Ian Reddin & Stephen Henderson & Cindy Dong & Nerissa Kirkwood & Maxmilan Jeyakumar & Daniela Rothschild Rodriguez & Natalia Gonzalez Martinez & Jacqueline McDermott & Xiaoping Su, 2022. "Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Jingyun Quan & Xiaoxia Wen & Guomei Su & Yu Zhong & Tong Huang & Zhilin Xiong & Jiewen Huang & Yingying Lv & Shihai Li & Shuhua Luo & Chaole Luo & Xin Cai & Xianwen Lai & Yuanyuan Xiang & Song Guo Zhe, 2023. "Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Lining Liang & Hao Sun & Wei Zhang & Mengdan Zhang & Xiao Yang & Rui Kuang & Hui Zheng, 2016. "Meta-Analysis of EMT Datasets Reveals Different Types of EMT," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-22, June.

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