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Foreign DNA capture during CRISPR–Cas adaptive immunity

Author

Listed:
  • James K. Nuñez

    (University of California, Berkeley)

  • Lucas B. Harrington

    (University of California, Berkeley)

  • Philip J. Kranzusch

    (University of California, Berkeley
    Howard Hughes Medical Institute, University of California, Berkeley)

  • Alan N. Engelman

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Jennifer A. Doudna

    (University of California, Berkeley
    Howard Hughes Medical Institute, University of California, Berkeley
    University of California, Berkeley
    Lawrence Berkeley National Laboratory)

Abstract

The structure of the Cas1–Cas2 complex bound to a protospacer sequence illustrates how foreign DNA is captured and measured by bacterial proteins in preparation for integration into CRISPR loci.

Suggested Citation

  • James K. Nuñez & Lucas B. Harrington & Philip J. Kranzusch & Alan N. Engelman & Jennifer A. Doudna, 2015. "Foreign DNA capture during CRISPR–Cas adaptive immunity," Nature, Nature, vol. 527(7579), pages 535-538, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7579:d:10.1038_nature15760
    DOI: 10.1038/nature15760
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    Cited by:

    1. Mingfang Bi & Wenjing Su & Jiafu Li & Xiaobing Mo, 2024. "Insights into the inhibition of protospacer integration via direct interaction between Cas2 and AcrVA5," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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