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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Author

Listed:
  • Shiran Rabinovich

    (Weizmann Institute of Science)

  • Lital Adler

    (Weizmann Institute of Science)

  • Keren Yizhak

    (The Blavatnik School of Computer Science, Tel Aviv University)

  • Alona Sarver

    (Weizmann Institute of Science)

  • Alon Silberman

    (Weizmann Institute of Science)

  • Shani Agron

    (Weizmann Institute of Science)

  • Noa Stettner

    (Weizmann Institute of Science)

  • Qin Sun

    (Baylor College of Medicine, Houston)

  • Alexander Brandis

    (Biological Services, Weizmann Institute of Science)

  • Daniel Helbling

    (Human and Molecular Genetic and Biochemistry Center, Medical College Wisconsin)

  • Stanley Korman

    (Genetic and Metabolic Center, Hadassah Medical Center)

  • Shalev Itzkovitz

    (Weizmann Institute of Science)

  • David Dimmock

    (Human and Molecular Genetic and Biochemistry Center, Medical College Wisconsin)

  • Igor Ulitsky

    (Weizmann Institute of Science)

  • Sandesh C. S. Nagamani

    (Baylor College of Medicine, Houston
    Texas Children’s Hospital)

  • Eytan Ruppin

    (The Blavatnik School of Computer Science, Tel Aviv University
    The Sackler School of Medicine, Tel Aviv University
    University of Maryland, College Park)

  • Ayelet Erez

    (Weizmann Institute of Science)

Abstract

ASS1, a urea cycle enzyme, promotes cancer cell proliferation by facilitating pyrimidine synthesis via CAD (carbamoyl-phosphate synthase 2, aspartate transcarbamylase, and dihydroorotase complex) activation.

Suggested Citation

  • Shiran Rabinovich & Lital Adler & Keren Yizhak & Alona Sarver & Alon Silberman & Shani Agron & Noa Stettner & Qin Sun & Alexander Brandis & Daniel Helbling & Stanley Korman & Shalev Itzkovitz & David , 2015. "Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis," Nature, Nature, vol. 527(7578), pages 379-383, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7578:d:10.1038_nature15529
    DOI: 10.1038/nature15529
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    Cited by:

    1. Donglin Ding & Alexandra M. Blee & Jianong Zhang & Yunqian Pan & Nicole A. Becker & L. James Maher & Rafael Jimenez & Liguo Wang & Haojie Huang, 2023. "Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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