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DNA-dependent formation of transcription factor pairs alters their binding specificity

Author

Listed:
  • Arttu Jolma

    (Karolinska Institutet)

  • Yimeng Yin

    (Karolinska Institutet)

  • Kazuhiro R. Nitta

    (Karolinska Institutet)

  • Kashyap Dave

    (Karolinska Institutet)

  • Alexander Popov

    (European Synchrotron Radiation Facility)

  • Minna Taipale

    (Karolinska Institutet)

  • Martin Enge

    (Karolinska Institutet)

  • Teemu Kivioja

    (Genome-Scale Biology Program, University of Helsinki)

  • Ekaterina Morgunova

    (Karolinska Institutet)

  • Jussi Taipale

    (Karolinska Institutet
    Genome-Scale Biology Program, University of Helsinki)

Abstract

A high-throughput analysis of DNA binding in over 9,000 interacting transcription factor pairs reveals that the interactions are often actively mediated by the DNA itself and the composite DNA sites recognized are different from the individual motifs of each transcription factor.

Suggested Citation

  • Arttu Jolma & Yimeng Yin & Kazuhiro R. Nitta & Kashyap Dave & Alexander Popov & Minna Taipale & Martin Enge & Teemu Kivioja & Ekaterina Morgunova & Jussi Taipale, 2015. "DNA-dependent formation of transcription factor pairs alters their binding specificity," Nature, Nature, vol. 527(7578), pages 384-388, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7578:d:10.1038_nature15518
    DOI: 10.1038/nature15518
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    Cited by:

    1. Siqian Feng & Chaitanya Rastogi & Ryan Loker & William J. Glassford & H. Tomas Rube & Harmen J. Bussemaker & Richard S. Mann, 2022. "Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Anna Berenson & Ryan Lane & Luis F. Soto-Ugaldi & Mahir Patel & Cosmin Ciausu & Zhaorong Li & Yilin Chen & Sakshi Shah & Clarissa Santoso & Xing Liu & Kerstin Spirohn & Tong Hao & David E. Hill & Marc, 2023. "Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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