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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

Author

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  • Tina Thorslund

    (Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Anita Ripplinger

    (Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Saskia Hoffmann

    (Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Thomas Wild

    (Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Michael Uckelmann

    (Cancer Genomics Center, Netherlands Cancer Institute)

  • Bine Villumsen

    (Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Takeo Narita

    (Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Titia K. Sixma

    (Cancer Genomics Center, Netherlands Cancer Institute)

  • Chunaram Choudhary

    (Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Simon Bekker-Jensen

    (Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Niels Mailand

    (Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

Abstract

At the initiation of DNA double-strand break repair, a number of ubiquitylation events occur; here, the RNF8 ubiquitin E3 ligase and the ubiquitin-conjugating E2 enzyme, UBC13, are shown to primarily modify H1-type linker histones, via a K63 linkage.

Suggested Citation

  • Tina Thorslund & Anita Ripplinger & Saskia Hoffmann & Thomas Wild & Michael Uckelmann & Bine Villumsen & Takeo Narita & Titia K. Sixma & Chunaram Choudhary & Simon Bekker-Jensen & Niels Mailand, 2015. "Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage," Nature, Nature, vol. 527(7578), pages 389-393, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7578:d:10.1038_nature15401
    DOI: 10.1038/nature15401
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    Cited by:

    1. Tingting Cui & Yu Zhang & Geng Qin & Yue Wei & Jie Yang & Ying Huang & Jinsong Ren & Xiaogang Qu, 2023. "A neutrophil mimicking metal-porphyrin-based nanodevice loaded with porcine pancreatic elastase for cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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