IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v527y2015i7577d10.1038_nature15711.html
   My bibliography  Save this article

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

Author

Listed:
  • Jin-Hua Sun

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Donald R. O’Boyle II

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Robert A. Fridell

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • David R. Langley

    (Computer-Assisted Drug Design, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Chunfu Wang

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Susan B. Roberts

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Peter Nower

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Benjamin M. Johnson

    (Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Frederic Moulin

    (Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Michelle J. Nophsker

    (Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Ying-Kai Wang

    (Leads Discovery and Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Mengping Liu

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Karen Rigat

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Yong Tu

    (Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Piyasena Hewawasam

    (Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • John Kadow

    (Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Nicholas A. Meanwell

    (Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Mark Cockett

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Julie A. Lemm

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Melissa Kramer

    (Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Makonen Belema

    (Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway)

  • Min Gao

    (Bristol-Myers Squibb Research and Development, 5 Research Parkway)

Abstract

The drug daclatasvir (DCV), which inhibits the hepatitis C virus (HCV) non-structural protein 5A (NS5A), can successfully reduce viral load in patients; here, a combination of DCV and an NS5A analogue is shown to enhance DCV potency on multiple genotypes and overcome resistance in vitro and in a mouse model.

Suggested Citation

  • Jin-Hua Sun & Donald R. O’Boyle II & Robert A. Fridell & David R. Langley & Chunfu Wang & Susan B. Roberts & Peter Nower & Benjamin M. Johnson & Frederic Moulin & Michelle J. Nophsker & Ying-Kai Wang , 2015. "Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A," Nature, Nature, vol. 527(7577), pages 245-248, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15711
    DOI: 10.1038/nature15711
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature15711
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature15711?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15711. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.