IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v527y2015i7577d10.1038_nature15698.html
   My bibliography  Save this article

Basomedial amygdala mediates top-down control of anxiety and fear

Author

Listed:
  • Avishek Adhikari

    (Stanford University
    CNC Program, Stanford University)

  • Talia N. Lerner

    (Stanford University
    CNC Program, Stanford University)

  • Joel Finkelstein

    (Stanford University)

  • Sally Pak

    (Stanford University)

  • Joshua H. Jennings

    (Stanford University
    CNC Program, Stanford University)

  • Thomas J. Davidson

    (Stanford University
    CNC Program, Stanford University)

  • Emily Ferenczi

    (Stanford University
    Neurosciences Program, Stanford University)

  • Lisa A. Gunaydin

    (Stanford University
    Neurosciences Program, Stanford University)

  • Julie J. Mirzabekov

    (Stanford University)

  • Li Ye

    (Stanford University
    CNC Program, Stanford University)

  • Sung-Yon Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Anna Lei

    (Stanford University)

  • Karl Deisseroth

    (Stanford University
    CNC Program, Stanford University
    Neurosciences Program, Stanford University
    Stanford University)

Abstract

Activation of the ventral medial prefrontal cortex–basomedial amygdala pathway is shown to suppress anxiety and fear-related freezing in mice, thus identifying the basomedial amygdala (and not intercalated cells, as posited by earlier models) as a novel target of top-down control.

Suggested Citation

  • Avishek Adhikari & Talia N. Lerner & Joel Finkelstein & Sally Pak & Joshua H. Jennings & Thomas J. Davidson & Emily Ferenczi & Lisa A. Gunaydin & Julie J. Mirzabekov & Li Ye & Sung-Yon Kim & Anna Lei , 2015. "Basomedial amygdala mediates top-down control of anxiety and fear," Nature, Nature, vol. 527(7577), pages 179-185, November.
  • Handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15698
    DOI: 10.1038/nature15698
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature15698
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature15698?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Robert N. Fetcho & Baila S. Hall & David J. Estrin & Alexander P. Walsh & Peter J. Schuette & Jesse Kaminsky & Ashna Singh & Jacob Roshgodal & Charlotte C. Bavley & Viraj Nadkarni & Susan Antigua & Th, 2023. "Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Bob Bramson & Sjoerd Meijer & Annelies Nuland & Ivan Toni & Karin Roelofs, 2023. "Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Nahoko Kuga & Ryota Nakayama & Shota Morikawa & Haruya Yagishita & Daichi Konno & Hiromi Shiozaki & Natsumi Honjoya & Yuji Ikegaya & Takuya Sasaki, 2023. "Hippocampal sharp wave ripples underlie stress susceptibility in male mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15698. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.