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Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Author

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  • Dongjun Peng

    (University of Michigan School of Medicine)

  • Ilona Kryczek

    (University of Michigan School of Medicine
    Graduate Program in Immunology, University of Michigan)

  • Nisha Nagarsheth

    (University of Michigan School of Medicine
    Graduate Program in Immunology, University of Michigan)

  • Lili Zhao

    (University of Michigan School of Medicine)

  • Shuang Wei

    (University of Michigan School of Medicine)

  • Weimin Wang

    (University of Michigan School of Medicine)

  • Yuqing Sun

    (University of Michigan School of Medicine)

  • Ende Zhao

    (University of Michigan School of Medicine)

  • Linda Vatan

    (University of Michigan School of Medicine)

  • Wojciech Szeliga

    (University of Michigan School of Medicine)

  • Jan Kotarski

    (Medical University in Lublin)

  • Rafał Tarkowski

    (Medical University in Lublin)

  • Yali Dou

    (University of Michigan School of Medicine)

  • Kathleen Cho

    (University of Michigan School of Medicine
    The University of Michigan Comprehensive Cancer Center, University of Michigan)

  • Sharon Hensley-Alford

    (Henry Ford Health System)

  • Adnan Munkarah

    (Henry Ford Health System)

  • Rebecca Liu

    (The University of Michigan Comprehensive Cancer Center, University of Michigan
    University of Michigan School of Medicine)

  • Weiping Zou

    (University of Michigan School of Medicine
    Graduate Program in Immunology, University of Michigan
    The University of Michigan Comprehensive Cancer Center, University of Michigan
    Graduate Program in Tumor Biology, University of Michigan)

Abstract

Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

Suggested Citation

  • Dongjun Peng & Ilona Kryczek & Nisha Nagarsheth & Lili Zhao & Shuang Wei & Weimin Wang & Yuqing Sun & Ende Zhao & Linda Vatan & Wojciech Szeliga & Jan Kotarski & Rafał Tarkowski & Yali Dou & Kathleen , 2015. "Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy," Nature, Nature, vol. 527(7577), pages 249-253, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15520
    DOI: 10.1038/nature15520
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    Citations

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    Cited by:

    1. Hanhan Ning & Shan Huang & Yang Lei & Renyong Zhi & Han Yan & Jiaxing Jin & Zhenyu Hu & Kaimin Guo & Jinhua Liu & Jie Yang & Zhe Liu & Yi Ba & Xin Gao & Deqing Hu, 2022. "Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Yousef Zakharia & Eric A. Singer & Satwik Acharyya & Rohan Garje & Monika Joshi & David Peace & Veera Baladandayuthapani & Annesha Majumdar & Xiong Li & Claudia Lalancette & Ilona Kryczek & Weiping Zo, 2024. "Durvalumab and guadecitabine in advanced clear cell renal cell carcinoma: results from the phase Ib/II study BTCRC-GU16-043," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Yazhong Cui & Yang Miao & Longzhi Cao & Lifang Guo & Yue Cui & Chuanzhe Yan & Zhi Zeng & Mo Xu & Ting Han, 2023. "Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Dae Joong Kim & Swetha Anandh & Jamie L. Null & Piotr Przanowski & Sanchita Bhatnagar & Pankaj Kumar & Sarah E. Shelton & Erin E. Grundy & Katherine B. Chiappinelli & Roger D. Kamm & David A. Barbie &, 2023. "Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Cang Li & Zhengyu Wang & Licheng Yao & Xingyu Lin & Yongping Jian & Yujia Li & Jie Zhang & Jingwei Shao & Phuc D. Tran & James R. Hagman & Meng Cao & Yusheng Cong & Hong-yu Li & Colin R. Goding & Zhi-, 2024. "Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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