IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v527y2015i7577d10.1038_nature15520.html
   My bibliography  Save this article

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Author

Listed:
  • Dongjun Peng

    (University of Michigan School of Medicine)

  • Ilona Kryczek

    (University of Michigan School of Medicine
    Graduate Program in Immunology, University of Michigan)

  • Nisha Nagarsheth

    (University of Michigan School of Medicine
    Graduate Program in Immunology, University of Michigan)

  • Lili Zhao

    (University of Michigan School of Medicine)

  • Shuang Wei

    (University of Michigan School of Medicine)

  • Weimin Wang

    (University of Michigan School of Medicine)

  • Yuqing Sun

    (University of Michigan School of Medicine)

  • Ende Zhao

    (University of Michigan School of Medicine)

  • Linda Vatan

    (University of Michigan School of Medicine)

  • Wojciech Szeliga

    (University of Michigan School of Medicine)

  • Jan Kotarski

    (Medical University in Lublin)

  • Rafał Tarkowski

    (Medical University in Lublin)

  • Yali Dou

    (University of Michigan School of Medicine)

  • Kathleen Cho

    (University of Michigan School of Medicine
    The University of Michigan Comprehensive Cancer Center, University of Michigan)

  • Sharon Hensley-Alford

    (Henry Ford Health System)

  • Adnan Munkarah

    (Henry Ford Health System)

  • Rebecca Liu

    (The University of Michigan Comprehensive Cancer Center, University of Michigan
    University of Michigan School of Medicine)

  • Weiping Zou

    (University of Michigan School of Medicine
    Graduate Program in Immunology, University of Michigan
    The University of Michigan Comprehensive Cancer Center, University of Michigan
    Graduate Program in Tumor Biology, University of Michigan)

Abstract

Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

Suggested Citation

  • Dongjun Peng & Ilona Kryczek & Nisha Nagarsheth & Lili Zhao & Shuang Wei & Weimin Wang & Yuqing Sun & Ende Zhao & Linda Vatan & Wojciech Szeliga & Jan Kotarski & Rafał Tarkowski & Yali Dou & Kathleen , 2015. "Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy," Nature, Nature, vol. 527(7577), pages 249-253, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15520
    DOI: 10.1038/nature15520
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature15520
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature15520?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dae Joong Kim & Swetha Anandh & Jamie L. Null & Piotr Przanowski & Sanchita Bhatnagar & Pankaj Kumar & Sarah E. Shelton & Erin E. Grundy & Katherine B. Chiappinelli & Roger D. Kamm & David A. Barbie &, 2023. "Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Cang Li & Zhengyu Wang & Licheng Yao & Xingyu Lin & Yongping Jian & Yujia Li & Jie Zhang & Jingwei Shao & Phuc D. Tran & James R. Hagman & Meng Cao & Yusheng Cong & Hong-yu Li & Colin R. Goding & Zhi-, 2024. "Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Hanhan Ning & Shan Huang & Yang Lei & Renyong Zhi & Han Yan & Jiaxing Jin & Zhenyu Hu & Kaimin Guo & Jinhua Liu & Jie Yang & Zhe Liu & Yi Ba & Xin Gao & Deqing Hu, 2022. "Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Yousef Zakharia & Eric A. Singer & Satwik Acharyya & Rohan Garje & Monika Joshi & David Peace & Veera Baladandayuthapani & Annesha Majumdar & Xiong Li & Claudia Lalancette & Ilona Kryczek & Weiping Zo, 2024. "Durvalumab and guadecitabine in advanced clear cell renal cell carcinoma: results from the phase Ib/II study BTCRC-GU16-043," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Yazhong Cui & Yang Miao & Longzhi Cao & Lifang Guo & Yue Cui & Chuanzhe Yan & Zhi Zeng & Mo Xu & Ting Han, 2023. "Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15520. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.