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Structural insight into substrate preference for TET-mediated oxidation

Author

Listed:
  • Lulu Hu

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
    State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University)

  • Junyan Lu

    (Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Jingdong Cheng

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Qinhui Rao

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Ze Li

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Haifeng Hou

    (Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences)

  • Zhiyong Lou

    (Laboratory of Structural Biology, Tsinghua University
    MOE Laboratory of Protein Science, School of Medicine, Tsinghua University)

  • Lei Zhang

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Wei Li

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University)

  • Wei Gong

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Mengjie Liu

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Chang Sun

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Xiaotong Yin

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Jie Li

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Xiangshi Tan

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University)

  • Pengcheng Wang

    (University of California-Riverside)

  • Yinsheng Wang

    (University of California-Riverside)

  • Dong Fang

    (Theoretical Chemistry Institute, University of Wisconsin-Madison, 1101 University Avenue)

  • Qiang Cui

    (Theoretical Chemistry Institute, University of Wisconsin-Madison, 1101 University Avenue)

  • Pengyuan Yang

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University)

  • Chuan He

    (The University of Chicago
    Howard Hughes Medical Institute, The University of Chicago)

  • Hualiang Jiang

    (Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Cheng Luo

    (Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Yanhui Xu

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
    State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University)

Abstract

In DNA demethylation, human TET proteins are evolutionarily tuned to be less reactive towards 5hmC and facilitate its generation as a potentially stable mark for regulatory functions.

Suggested Citation

  • Lulu Hu & Junyan Lu & Jingdong Cheng & Qinhui Rao & Ze Li & Haifeng Hou & Zhiyong Lou & Lei Zhang & Wei Li & Wei Gong & Mengjie Liu & Chang Sun & Xiaotong Yin & Jie Li & Xiangshi Tan & Pengcheng Wang , 2015. "Structural insight into substrate preference for TET-mediated oxidation," Nature, Nature, vol. 527(7576), pages 118-122, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7576:d:10.1038_nature15713
    DOI: 10.1038/nature15713
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