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Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Author

Listed:
  • Jerome Mertens

    (State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University
    The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Qiu-Wen Wang

    (State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University)

  • Yongsung Kim

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Diana X. Yu

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Son Pham

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Bo Yang

    (State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University)

  • Yi Zheng

    (State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University)

  • Kenneth E. Diffenderfer

    (The Salk Institute for Biological Studies, Stem Cell Core)

  • Jian Zhang

    (Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences)

  • Sheila Soltani

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Tameji Eames

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Simon T. Schafer

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Leah Boyer

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Maria C. Marchetto

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • John I. Nurnberger

    (Indiana University)

  • Joseph R. Calabrese

    (Case Western Reserve University)

  • Ketil J. Oedegaard

    (Section for Psychiatry, University of Bergen and K.G. Jebsen Centre for Research on Neuropsychiatric Disorders)

  • Michael J. McCarthy

    (VA San Diego Healthcare System
    University of California San Diego)

  • Peter P. Zandi

    (Johns Hopkins University)

  • Martin Alda

    (Dalhousie University)

  • Caroline M. Nievergelt

    (University of California San Diego)

  • Shuangli Mi

    (Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences)

  • Kristen J. Brennand

    (Mount Sinai School of Medicine)

  • John R. Kelsoe

    (VA San Diego Healthcare System
    University of California San Diego)

  • Fred H. Gage

    (The Salk Institute for Biological Studies, Laboratory of Genetics)

  • Jun Yao

    (State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University
    The Salk Institute for Biological Studies, Laboratory of Genetics
    Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal University)

Abstract

A neuronal model of bipolar disorder based on induced pluripotent stem cell (iPSC) technology finds hyperactive action-potential firing and differential responsiveness to lithium in iPSC-derived neurons from patients with bipolar disorder.

Suggested Citation

  • Jerome Mertens & Qiu-Wen Wang & Yongsung Kim & Diana X. Yu & Son Pham & Bo Yang & Yi Zheng & Kenneth E. Diffenderfer & Jian Zhang & Sheila Soltani & Tameji Eames & Simon T. Schafer & Leah Boyer & Mari, 2015. "Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder," Nature, Nature, vol. 527(7576), pages 95-99, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7576:d:10.1038_nature15526
    DOI: 10.1038/nature15526
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