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Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Author

Listed:
  • Lin Zhang

    (The University of Texas M. D. Anderson Cancer Center
    Cancer Biology Program, Graduate School of Biomedical Sciences)

  • Siyuan Zhang

    (The University of Texas M. D. Anderson Cancer Center
    University of Notre Dame)

  • Jun Yao

    (The University of Texas M. D. Anderson Cancer Center)

  • Frank J. Lowery

    (The University of Texas M. D. Anderson Cancer Center
    Cancer Biology Program, Graduate School of Biomedical Sciences)

  • Qingling Zhang

    (The University of Texas M. D. Anderson Cancer Center)

  • Wen-Chien Huang

    (The University of Texas M. D. Anderson Cancer Center)

  • Ping Li

    (The University of Texas M. D. Anderson Cancer Center)

  • Min Li

    (The University of Texas M. D. Anderson Cancer Center)

  • Xiao Wang

    (The University of Texas M. D. Anderson Cancer Center)

  • Chenyu Zhang

    (The University of Texas M. D. Anderson Cancer Center)

  • Hai Wang

    (The University of Texas M. D. Anderson Cancer Center)

  • Kenneth Ellis

    (The University of Texas M. D. Anderson Cancer Center)

  • Mujeeburahiman Cheerathodi

    (The University of Texas M. D. Anderson Cancer Center)

  • Joseph H. McCarty

    (The University of Texas M. D. Anderson Cancer Center)

  • Diane Palmieri

    (Woman’s Malignancies Branch, National Cancer Institute)

  • Jodi Saunus

    (The University of Queensland Centre for Clinical Research)

  • Sunil Lakhani

    (The University of Queensland Centre for Clinical Research
    The School of Medicine and Pathology Queensland
    The Royal Brisbane and Women’s Hospital)

  • Suyun Huang

    (The University of Texas M. D. Anderson Cancer Center)

  • Aysegul A. Sahin

    (The University of Texas M. D. Anderson Cancer Center)

  • Kenneth D. Aldape

    (The University of Texas M. D. Anderson Cancer Center)

  • Patricia S. Steeg

    (Woman’s Malignancies Branch, National Cancer Institute)

  • Dihua Yu

    (The University of Texas M. D. Anderson Cancer Center
    Cancer Biology Program, Graduate School of Biomedical Sciences
    Center for Molecular Medicine, China Medical University)

Abstract

Expression of the tumour suppressor PTEN in disseminated primary tumour cells is lost after tumour cells metastasize to the brain, with downregulation instigated by microRNAs from astrocytes, which are transferred from cell to cell by exosomes; these findings reveal the dynamic nature of metastatic cancer cells when adapting to a new tissue environment.

Suggested Citation

  • Lin Zhang & Siyuan Zhang & Jun Yao & Frank J. Lowery & Qingling Zhang & Wen-Chien Huang & Ping Li & Min Li & Xiao Wang & Chenyu Zhang & Hai Wang & Kenneth Ellis & Mujeeburahiman Cheerathodi & Joseph H, 2015. "Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth," Nature, Nature, vol. 527(7576), pages 100-104, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7576:d:10.1038_nature15376
    DOI: 10.1038/nature15376
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    Citations

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    Cited by:

    1. Weili Ma & Maria Cecília Oliveira-Nunes & Ke Xu & Andrew Kossenkov & Benjamin C. Reiner & Richard C. Crist & James Hayden & Qing Chen, 2023. "Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Qing Li & Xiao-Xin Zhang & Li-Peng Hu & Bo Ni & Dong-Xue Li & Xu Wang & Shu-Heng Jiang & Hui Li & Min-Wei Yang & Yong-Sheng Jiang & Chun-Jie Xu & Xue-Li Zhang & Yan-Li Zhang & Pei-Qi Huang & Qin Yang , 2023. "Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Xianhui Ruan & Wei Yan & Minghui Cao & Ray Anthony M. Daza & Miranda Y. Fong & Kaifu Yang & Jun Wu & Xuxiang Liu & Melanie Palomares & Xiwei Wu & Arthur Li & Yuan Chen & Rahul Jandial & Nicholas C. Sp, 2024. "Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Ilya G. Serebriiskii & Valery Pavlov & Rossella Tricarico & Grigorii Andrianov & Emmanuelle Nicolas & Mitchell I. Parker & Justin Newberg & Garrett Frampton & Joshua E. Meyer & Erica A. Golemis, 2022. "Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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