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Organometallic palladium reagents for cysteine bioconjugation

Author

Listed:
  • Ekaterina V. Vinogradova

    (Massachusetts Institute of Technology)

  • Chi Zhang

    (Massachusetts Institute of Technology)

  • Alexander M. Spokoyny

    (Massachusetts Institute of Technology
    †Present address: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.)

  • Bradley L. Pentelute

    (Massachusetts Institute of Technology)

  • Stephen L. Buchwald

    (Massachusetts Institute of Technology)

Abstract

Palladium(ii) complexes can be used in efficient and highly selective cysteine conjugation reactions that are rapid and robust, and the resulting aryl bioconjugates are stable towards acids, bases, oxidants and external thiol nucleophiles.

Suggested Citation

  • Ekaterina V. Vinogradova & Chi Zhang & Alexander M. Spokoyny & Bradley L. Pentelute & Stephen L. Buchwald, 2015. "Organometallic palladium reagents for cysteine bioconjugation," Nature, Nature, vol. 526(7575), pages 687-691, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7575:d:10.1038_nature15739
    DOI: 10.1038/nature15739
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    Cited by:

    1. Mengzhun Guo & Kai Zhao & Liang Guo & Rui Zhou & Qiuju He & Kuan Lu & Tian Li & Dandan Liu & Jinfeng Chen & Jing Tang & Xin Fu & Jinyun Zhou & Bei Zheng & Samuel I. Mann & Yongdeng Zhang & Jing Huang , 2023. "Copper assisted sequence-specific chemical protein conjugation at a single backbone amide," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Guangjun Bao & Xinyi Song & Yiping Li & Zeyuan He & Quan Zuo & Ruiyao E & Tingli Yu & Kai Li & Junqiu Xie & Wangsheng Sun & Rui Wang, 2024. "Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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