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Caspase target drives pyroptosis

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  • Petr Broz

    (Petr Broz is at the Biozentrum, University of Basel, CH-4056 Basel, Switzerland.)

Abstract

Inflammatory caspase proteins help to control pathogen replication by triggering pyroptotic cell death. It now emerges that cleavage of the caspase substrate gasdermin D is sufficient to induce pyroptosis. See Articles p.660 & p.666

Suggested Citation

  • Petr Broz, 2015. "Caspase target drives pyroptosis," Nature, Nature, vol. 526(7575), pages 642-643, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7575:d:10.1038_nature15632
    DOI: 10.1038/nature15632
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    Cited by:

    1. Stefania A. Mari & Kristyna Pluhackova & Joka Pipercevic & Matthew Leipner & Sebastian Hiller & Andreas Engel & Daniel J. Müller, 2022. "Gasdermin-A3 pore formation propagates along variable pathways," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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