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Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

Author

Listed:
  • Tien Peng

    (University of Pennsylvania
    †Present address: University of California, San Francisco, 513 Parnassus Avenue, HSE Building, Room 1312, Box 0130, San Francisco, California 94143, USA (T.P.).)

  • David B. Frank

    (University of Pennsylvania)

  • Rachel S. Kadzik

    (University of Pennsylvania)

  • Michael P. Morley

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania
    Penn Cardiovascular Institute, University of Pennsylvania)

  • Komal S. Rathi

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania
    Penn Cardiovascular Institute, University of Pennsylvania)

  • Tao Wang

    (Penn Cardiovascular Institute, University of Pennsylvania)

  • Su Zhou

    (Penn Cardiovascular Institute, University of Pennsylvania)

  • Lan Cheng

    (Penn Cardiovascular Institute, University of Pennsylvania)

  • Min Min Lu

    (Penn Cardiovascular Institute, University of Pennsylvania)

  • Edward E. Morrisey

    (University of Pennsylvania
    University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania
    Penn Cardiovascular Institute, University of Pennsylvania)

Abstract

It is generally thought that the quiescence of tissue is not actively maintained, but rather a state reflecting the absence of proliferative signal; here the authors find that quiescence is actively maintained by paracrine hedgehog signalling provided by the epithelium in the mouse adult lung, and that hedgehog is dynamically regulated during injury repair and resolution for proper restoration of tissue homeostasis after injury.

Suggested Citation

  • Tien Peng & David B. Frank & Rachel S. Kadzik & Michael P. Morley & Komal S. Rathi & Tao Wang & Su Zhou & Lan Cheng & Min Min Lu & Edward E. Morrisey, 2015. "Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration," Nature, Nature, vol. 526(7574), pages 578-582, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7574:d:10.1038_nature14984
    DOI: 10.1038/nature14984
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    Cited by:

    1. Xin Pan & Lan Wang & Juntang Yang & Yingge Li & Min Xu & Chenxi Liang & Lulu Liu & Zhongzheng Li & Cong Xia & Jiaojiao Pang & Mengyuan Wang & Meng Li & Saiya Guo & Peishuo Yan & Chen Ding & Ivan O. Ro, 2024. "TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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