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RAF inhibitors that evade paradoxical MAPK pathway activation

Author

Listed:
  • Chao Zhang

    (Plexxikon Inc.)

  • Wayne Spevak

    (Plexxikon Inc.)

  • Ying Zhang

    (Plexxikon Inc.)

  • Elizabeth A. Burton

    (Plexxikon Inc.)

  • Yan Ma

    (Plexxikon Inc.)

  • Gaston Habets

    (Plexxikon Inc.)

  • Jiazhong Zhang

    (Plexxikon Inc.)

  • Jack Lin

    (Plexxikon Inc.)

  • Todd Ewing

    (Plexxikon Inc.)

  • Bernice Matusow

    (Plexxikon Inc.)

  • Garson Tsang

    (Plexxikon Inc.)

  • Adhirai Marimuthu

    (Plexxikon Inc.)

  • Hanna Cho

    (Plexxikon Inc.)

  • Guoxian Wu

    (Plexxikon Inc.)

  • Weiru Wang

    (Plexxikon Inc.)

  • Daniel Fong

    (Plexxikon Inc.)

  • Hoa Nguyen

    (Plexxikon Inc.)

  • Songyuan Shi

    (Plexxikon Inc.)

  • Patrick Womack

    (Plexxikon Inc.)

  • Marika Nespi

    (Plexxikon Inc.)

  • Rafe Shellooe

    (Plexxikon Inc.)

  • Heidi Carias

    (Plexxikon Inc.)

  • Ben Powell

    (Plexxikon Inc.)

  • Emily Light

    (Plexxikon Inc.)

  • Laura Sanftner

    (Plexxikon Inc.)

  • Jason Walters

    (Plexxikon Inc.)

  • James Tsai

    (Plexxikon Inc.)

  • Brian L. West

    (Plexxikon Inc.)

  • Gary Visor

    (Plexxikon Inc.)

  • Hamid Rezaei

    (Plexxikon Inc.)

  • Paul S. Lin

    (Plexxikon Inc.)

  • Keith Nolop

    (Plexxikon Inc.)

  • Prabha N. Ibrahim

    (Plexxikon Inc.)

  • Peter Hirth

    (Plexxikon Inc.)

  • Gideon Bollag

    (Plexxikon Inc.)

Abstract

Next-generation RAF inhibitors that inhibit oncogenic BRAF without inducing paradoxical pathway activation in cells with mutant RAS might yield improved safety and more durable efficacy.

Suggested Citation

  • Chao Zhang & Wayne Spevak & Ying Zhang & Elizabeth A. Burton & Yan Ma & Gaston Habets & Jiazhong Zhang & Jack Lin & Todd Ewing & Bernice Matusow & Garson Tsang & Adhirai Marimuthu & Hanna Cho & Guoxia, 2015. "RAF inhibitors that evade paradoxical MAPK pathway activation," Nature, Nature, vol. 526(7574), pages 583-586, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7574:d:10.1038_nature14982
    DOI: 10.1038/nature14982
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    Citations

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    Cited by:

    1. Revati Darp & Marc A. Vittoria & Neil J. Ganem & Craig J. Ceol, 2022. "Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Johanna Zerbib & Marica Rosaria Ippolito & Yonatan Eliezer & Giuseppina Feudis & Eli Reuveni & Anouk Savir Kadmon & Sara Martin & Sonia Viganò & Gil Leor & James Berstler & Julia Muenzner & Michael Mü, 2024. "Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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