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Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice

Author

Listed:
  • Shuang Hao

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Bin Tang

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Zhenyu Wu

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Kerstin Ure

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Yaling Sun

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Huifang Tao

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Yan Gao

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Akash J. Patel

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Daniel J. Curry

    (Baylor College of Medicine)

  • Rodney C. Samaco

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

  • Huda Y. Zoghbi

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine
    Baylor College of Medicine
    Program in Developmental Biology, Baylor College of Medicine)

  • Jianrong Tang

    (Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
    Baylor College of Medicine)

Abstract

Deep brain stimulation (DBS) of the fimbria–fornix—a region that provides input to the hippocampus—is shown to restore hippocampus-dependent memory and hippocampal long-term potentiation and neurogenesis in a mouse model of Rett syndrome, suggesting that DBS, which is already used in the treatment of several neurological conditions, could be a viable approach to mitigating cognitive impairment in Rett syndrome and other disorders of childhood intellectual disability.

Suggested Citation

  • Shuang Hao & Bin Tang & Zhenyu Wu & Kerstin Ure & Yaling Sun & Huifang Tao & Yan Gao & Akash J. Patel & Daniel J. Curry & Rodney C. Samaco & Huda Y. Zoghbi & Jianrong Tang, 2015. "Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice," Nature, Nature, vol. 526(7573), pages 430-434, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15694
    DOI: 10.1038/nature15694
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    Cited by:

    1. Eric Lowet & Krishnakanth Kondabolu & Samuel Zhou & Rebecca A. Mount & Yangyang Wang & Cara R. Ravasio & Xue Han, 2022. "Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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