IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v526y2015i7573d10.1038_nature15258.html
   My bibliography  Save this article

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer

Author

Listed:
  • Thomas Wiesner

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Medical University of Graz)

  • William Lee

    (Computational Biology Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Anna C. Obenauf

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

  • Leili Ran

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Rajmohan Murali

    (Memorial Sloan Kettering Cancer Center
    Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center)

  • Qi Fan Zhang

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Elissa W. P. Wong

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Wenhuo Hu

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Sasinya N. Scott

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Ronak H. Shah

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Iñigo Landa

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Julia Button

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    †Present address: Johns Hopkins School of Medicine, Baltimore, Maryland 21205-2196, USA)

  • Nathalie Lailler

    (Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center)

  • Andrea Sboner

    (Weill Cornell Medical College/New York Presbyterian Hospital
    Institute for Computational Biomedicine, Weill Cornell Medical College/New York Presbyterian Hospital
    Institute for Precision Medicine, Weill Cornell Medical College/New York Presbyterian Hospital)

  • Dong Gao

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Devan A. Murphy

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Zhen Cao

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Shipra Shukla

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Travis J. Hollmann

    (Memorial Sloan Kettering Cancer Center)

  • Lu Wang

    (Memorial Sloan Kettering Cancer Center)

  • Laetitia Borsu

    (Memorial Sloan Kettering Cancer Center)

  • Taha Merghoub

    (Immunology Program, Memorial Sloan Kettering Cancer Center)

  • Gary K. Schwartz

    (Herbert Irving Comprehensive Cancer Center, Columbia University Cancer Center)

  • Michael A. Postow

    (Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College)

  • Charlotte E. Ariyan

    (Memorial Sloan Kettering Cancer Center)

  • James A. Fagin

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College)

  • Deyou Zheng

    (Albert Einstein College of Medicine
    Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Marc Ladanyi

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Klaus J. Busam

    (Memorial Sloan Kettering Cancer Center)

  • Michael F. Berger

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center)

  • Yu Chen

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College)

  • Ping Chi

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College)

Abstract

A novel ALK transcript expressed in a subset of human cancers, arising from a de novo alternative transcription initiation site within the ALK gene, is described; the ALK transcript encodes three protein isoforms that stimulate tumorigenesis in vivo in mouse models; resultant tumours are sensitive to treatments with ALK inhibitors, indicating a possible therapeutic avenue for patients expressing these isoforms.

Suggested Citation

  • Thomas Wiesner & William Lee & Anna C. Obenauf & Leili Ran & Rajmohan Murali & Qi Fan Zhang & Elissa W. P. Wong & Wenhuo Hu & Sasinya N. Scott & Ronak H. Shah & Iñigo Landa & Julia Button & Nathalie L, 2015. "Alternative transcription initiation leads to expression of a novel ALK isoform in cancer," Nature, Nature, vol. 526(7573), pages 453-457, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15258
    DOI: 10.1038/nature15258
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature15258
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature15258?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Laia Simó-Riudalbas & Sandra Offner & Evarist Planet & Julien Duc & Laurence Abrami & Sagane Dind & Alexandre Coudray & Mairene Coto-Llerena & Caner Ercan & Salvatore Piscuoglio & Claus Lindbjerg Ande, 2022. "Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Zeyang Wang & Rui Fan & Angela Russo & Filippo M. Cernilogar & Alexander Nuber & Silvia Schirge & Irina Shcherbakova & Iva Dzhilyanova & Enes Ugur & Tobias Anton & Lisa Richter & Heinrich Leonhardt & , 2022. "Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Julia Schöpf & Sebastian Uhrig & Christoph E. Heilig & Kwang-Seok Lee & Tatjana Walther & Alexander Carazzato & Anna Maria Dobberkau & Dieter Weichenhan & Christoph Plass & Mark Hartmann & Gaurav D. D, 2024. "Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15258. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.