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Mediator kinase inhibition further activates super-enhancer-associated genes in AML

Author

Listed:
  • Henry E. Pelish

    (Harvard University)

  • Brian B. Liau

    (Harvard University)

  • Ioana I. Nitulescu

    (Harvard University)

  • Anupong Tangpeerachaikul

    (Harvard University)

  • Zachary C. Poss

    (University of Colorado)

  • Diogo H. Da Silva

    (Harvard University)

  • Brittany T. Caruso

    (Harvard University)

  • Alexander Arefolov

    (Harvard University)

  • Olugbeminiyi Fadeyi

    (Harvard University)

  • Amanda L. Christie

    (Lurie Family Imaging Center, Dana-Farber Cancer Institute)

  • Karrie Du

    (Harvard University)

  • Deepti Banka

    (Children's Hospital)

  • Elisabeth V. Schneider

    (Proteros Biostructures GmbH
    Max-Planck-Institut für Biochemie)

  • Anja Jestel

    (Proteros Biostructures GmbH)

  • Ge Zou

    (Harvard University)

  • Chong Si

    (Harvard University)

  • Christopher C. Ebmeier

    (University of Colorado)

  • Roderick T. Bronson

    (Dana-Farber Cancer Institute)

  • Andrei V. Krivtsov

    (Memorial Sloan Kettering Cancer Center)

  • Andrew G. Myers

    (Harvard University)

  • Nancy E. Kohl

    (Lurie Family Imaging Center, Dana-Farber Cancer Institute)

  • Andrew L. Kung

    (Columbia University Medical Center)

  • Scott A. Armstrong

    (Memorial Sloan Kettering Cancer Center)

  • Madeleine E. Lemieux

    (Bioinfo)

  • Dylan J. Taatjes

    (University of Colorado)

  • Matthew D. Shair

    (Harvard University)

Abstract

A small-molecule inhibitor of the Mediator-associated kinases CDK8 and CDK19 inhibits growth of acute myeloid leukaemia (AML) cells and induces upregulation of super-enhancer-associated genes with tumour suppressor and lineage-controlling functions; Mediator kinase inhibition therefore represents a promising therapeutic approach for AML.

Suggested Citation

  • Henry E. Pelish & Brian B. Liau & Ioana I. Nitulescu & Anupong Tangpeerachaikul & Zachary C. Poss & Diogo H. Da Silva & Brittany T. Caruso & Alexander Arefolov & Olugbeminiyi Fadeyi & Amanda L. Christ, 2015. "Mediator kinase inhibition further activates super-enhancer-associated genes in AML," Nature, Nature, vol. 526(7572), pages 273-276, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7572:d:10.1038_nature14904
    DOI: 10.1038/nature14904
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    Cited by:

    1. Shaela Wright & Xujie Zhao & Wojciech Rosikiewicz & Shelby Mryncza & Judith Hyle & Wenjie Qi & Zhenling Liu & Siqi Yi & Yong Cheng & Beisi Xu & Chunliang Li, 2023. "Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Edurne San José-Enériz & Naroa Gimenez-Camino & Obdulia Rabal & Leire Garate & Estibaliz Miranda & Nahia Gómez-Echarte & Fernando García & Stella Charalampopoulou & Elena Sáez & Amaia Vilas-Zornoza & , 2024. "Epigenetic-based differentiation therapy for Acute Myeloid Leukemia," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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